Morales-Doria M
Rev Infect Dis. 1987 Jan-Feb;9 Suppl 1:S131-3. doi: 10.1093/clinids/9.supplement_1.s131.
An open, comparative trial of two brief regimens of itraconazole for pityriasis versicolor was carried out. Twenty-four patients received 100 mg twice a day for five days, and 23 received 100 mg once a day for five days. Patients were enrolled in the study on the basis of the presence of clinical symptoms and positive findings on direct microscopic examination. Tolerance to the drug and mycologic and clinical outcome were assessed on days 6, 14, and 28 after the initiation of treatment. For 23 patients in each group, skin samples were negative for fungi by day 18. Clinical improvement was slow; first scaling disappeared and then erythema and inflammation. Dyschromia persisted during the observation period. Six patients had adverse reactions to treatment; none discontinued treatment.
进行了一项关于伊曲康唑两种短疗程方案治疗花斑糠疹的开放性对照试验。24例患者每天两次服用100毫克，共五天，23例患者每天一次服用100毫克，共五天。根据临床症状和直接镜检阳性结果纳入研究患者。在治疗开始后的第6天、14天和28天评估药物耐受性、真菌学和临床结果。每组23例患者在第18天时皮肤样本真菌检测呈阴性。临床改善缓慢；首先鳞屑消失，然后红斑和炎症消退。色素沉着在观察期持续存在。6例患者出现治疗不良反应；无人停止治疗。
