Estrada R A
Rev Infect Dis. 1987 Jan-Feb;9 Suppl 1:S128-30. doi: 10.1093/clinids/9.supplement_1.s128.
Forty-two patients with pityriasis versicolor were treated with itraconazole. Patients were allocated randomly to one of two groups; the first group (22 patients) received 200 mg of itraconazole per day for five days, and the second group (20 patients) received 100 mg per day for the same period. The study lasted 30 days. Each patient's clinical history was recorded before treatment. Wood's light examination was also done at this time and was repeated weekly. Direct microscopic examination of lesions was undertaken at the beginning, middle, and end of the trial. Specimens for cultures could be obtained from only 24 patients. The cure rate was 95% in the first group and 75% in the second. The difference between these rates was not significant, but the groups were small and the difference in dosage may ultimately be meaningful in terms of rates of cure. Itraconazole appears to be effective in a high percentage of cases of pityriasis versicolor.
42例花斑糠疹患者接受了伊曲康唑治疗。患者被随机分为两组；第一组（22例患者）每天服用200毫克伊曲康唑，共服用五天，第二组（20例患者）在同一时期每天服用100毫克。研究持续30天。治疗前记录每位患者的临床病史。此时还进行了伍德灯检查，并每周重复一次。在试验开始、中期和结束时对病变进行直接显微镜检查。仅从24例患者中获取了培养标本。第一组的治愈率为95%，第二组为75%。这些治愈率之间的差异不显著，但样本量较小，剂量差异最终可能对治愈率有意义。伊曲康唑在高比例的花斑糠疹病例中似乎是有效的。
