Department of Biological Sciences, Inha University, Incheon 22212, Korea.
Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA.
Int J Mol Sci. 2018 Aug 21;19(9):2472. doi: 10.3390/ijms19092472.
A common feature of the aging process is a decline in immune system performance. Extensive research has sought to elucidate how changes in adaptive immunity contribute to aging and to provide evidence showing that changes in innate immunity have an important role in the overall decline of net immune function. is an emerging model used to address questions related to immunosenescence via research that integrates its capacity for genetic dissection of aging with groundbreaking molecular biology related to innate immunity. Herein, we review information on the immunosenescence of and suggest its possible mechanisms that involve changes in insulin/IGF(insulin-like growth factor)-1 signaling, hormones such as juvenile hormone and 20-hydroxyecdysone, and feedback system degeneration. Lastly, the emerging role of microbiota on the regulation of immunity and aging in is discussed.
衰老过程的一个共同特征是免疫系统性能下降。大量研究试图阐明适应性免疫的变化如何导致衰老，并提供证据表明，固有免疫的变化在整体净免疫功能下降中起着重要作用。是一种新兴的模型，通过将其衰老的遗传剖析能力与先天免疫相关的开创性分子生物学相结合的研究，用于解决与免疫衰老相关的问题。在此，我们回顾了有关的免疫衰老信息，并提出了其可能的机制，包括胰岛素/IGF（胰岛素样生长因子）-1 信号转导、保幼激素和 20-羟基蜕皮酮等激素以及反馈系统退化的变化。最后，讨论了微生物群在调节和衰老中的新兴作用。
