Tripathi Lakshmi, Irorere Victor U, Marchant Roger, Banat Ibrahim M
School of Biomedical Sciences, Faculty of Life and Health Sciences, Ulster University, Coleraine, BT52 1SA, UK.
Biotechnol Lett. 2018 Dec;40(11-12):1441-1457. doi: 10.1007/s10529-018-2602-8. Epub 2018 Aug 25.
Surfactants and emulsifiers are surface-active compounds (SACs) which play an important role in various industrial processes and products due to their interfacial properties. Many of the chemical surfactants in use today are produced from non-renewable petrochemical feedstocks, while biosurfactants (BS) produced by microorganisms from renewable feedstocks are considered viable alternatives to petroleum based surfactants, due to their biodegradability and eco-friendly nature. However, some well-characterised BS producers are pathogenic and therefore, not appropriate for scaled-up production. Marine-derived BS have been found to be produced by non-pathogenic organisms making them attractive possibilities for exploitation in commercial products. Additionally, BS produced from marine bacteria may show excellent activity at extreme conditions (temperature, pH and salinity). Despite being non-pathogenic, marine-derived BS have not been exploited commercially due to their low yields, insufficient structural elucidation and uncharacterised genes. Therefore, optimization of BS production conditions in marine bacteria, characterization of the compounds produced as well as the genes involved in the biosynthesis are necessary to improve cost-efficiency and realise the industrial demands of SACs.
表面活性剂和乳化剂是表面活性化合物(SACs),由于其界面特性,它们在各种工业过程和产品中发挥着重要作用。当今使用的许多化学表面活性剂是由不可再生的石化原料生产的,而微生物从可再生原料生产的生物表面活性剂(BS)由于其生物可降解性和生态友好性,被认为是石油基表面活性剂的可行替代品。然而,一些特征明确的BS生产者具有致病性,因此不适合扩大生产。已发现海洋来源的BS由非致病生物产生,这使其在商业产品开发中具有诱人的可能性。此外,海洋细菌产生的BS在极端条件(温度、pH值和盐度)下可能表现出优异的活性。尽管海洋来源的BS无致病性,但由于其产量低、结构解析不足和基因未表征,尚未得到商业开发。因此,优化海洋细菌中BS的生产条件、表征所产生的化合物以及参与生物合成的基因,对于提高成本效益和实现SACs的工业需求是必要的。