豚鼠三叉神经节潜伏性单纯疱疹病毒感染的发病机制：年龄、被动免疫和氢化可的松的影响
Pathogenesis of latent herpes simplex virus infection of the trigeminal ganglion in guinea pigs: effects of age, passive immunization, and hydrocortisone.
作者信息
Tenser R B, Hsiung G D
出版信息
Infect Immun. 1977 Apr;16(1):69-74. doi: 10.1128/iai.16.1.69-74.1977.
Abstract
Latent herpes simplex virus (HSV) infection of the trigeminal ganglion, after corneal inoculation of virus, was investigated in guinea pigs. The effects of several factors on the establishment of ganglionic latency were investigated. Latently infected guinea pigs were clinically normal, and virus was isolated from the trigeminal ganglia by co-cultivation. It was found that newborn guinea pigs were significantly more susceptible than adult animals to the development of latent HSV infection of the trigeminal ganglion. The susceptibility of newborn guinea pigs was very much decreased, however, if they received passive immunization with immune serum or if they were born of actively immunized mothers. On the other hand, the susceptibility of adult animals, usually somewhat resistant to the development of latent HSV ganglionic infection, was markedly increased by the parenteral administration of hydrocortisone.
摘要
在豚鼠中，研究了角膜接种病毒后三叉神经节的潜伏性单纯疱疹病毒（HSV）感染情况。研究了几个因素对神经节潜伏感染建立的影响。潜伏感染的豚鼠临床正常，通过共培养从三叉神经节中分离出病毒。结果发现，新生豚鼠比成年动物对三叉神经节潜伏性HSV感染的发生明显更易感。然而，如果新生豚鼠接受免疫血清的被动免疫或其母亲为主动免疫的动物，则其易感性会大大降低。另一方面，成年动物通常对潜伏性HSV神经节感染的发生有一定抵抗力，经肠胃外给予氢化可的松后，其易感性明显增加。
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