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1
Retrovirus infections among patients treated in Britain with various clotting factors.在英国接受各种凝血因子治疗的患者中发生的逆转录病毒感染。
Br Med J (Clin Res Ed). 1986 Jul 19;293(6540):168-9. doi: 10.1136/bmj.293.6540.168.
2
Human T-lymphotropic retrovirus type III/lymphadenopathy-associated virus antibody. Association with hemophiliacs' immune status and blood component usage.
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3
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N Engl J Med. 1985 Feb 21;312(8):483-6. doi: 10.1056/NEJM198502213120805.
4
HTLV-III seropositivity in European haemophiliacs exposed to Factor VIII concentrate imported from the USA.
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Prevalence of antibodies to lymphadenopathy-AIDS virus in French haemophiliacs.
Vox Sang. 1985;49(2):161-3. doi: 10.1111/j.1423-0410.1985.tb00785.x.
6
HTLV-III antibody and T-cell subset ratios in haemophiliacs and their spouses.
Br J Haematol. 1986 Jun;63(2):347-52. doi: 10.1111/j.1365-2141.1986.tb05558.x.
7
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Prevalence of antibody to human T lymphotropic virus type III by risk group and area, United Kingdom 1978-84.1978 - 1984年英国按风险组和地区划分的人类嗜T淋巴细胞病毒III型抗体流行率。
Br Med J (Clin Res Ed). 1985 Apr 20;290(6476):1176-8. doi: 10.1136/bmj.290.6476.1176.
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Human T-lymphotropic virus type III (HTLV-III) infection in seronegative haemophiliacs after transfusion of factor VIII.输血后血清反应阴性血友病患者的人嗜T淋巴细胞病毒III型（HTLV-III）感染
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本文引用的文献

1
A retrospective study on transmission of adult T cell leukemia virus by blood transfusion: seroconversion in recipients.成人T细胞白血病病毒输血传播的回顾性研究：受血者血清阳转情况
Vox Sang. 1984;46(5):245-53. doi: 10.1111/j.1423-0410.1984.tb00083.x.
2
Pseudotypes of human T-cell leukemia virus types 1 and 2: neutralization by patients' sera.人类1型和2型T细胞白血病病毒假型：患者血清的中和作用
Proc Natl Acad Sci U S A. 1984 May;81(9):2886-9. doi: 10.1073/pnas.81.9.2886.
3
Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS.从艾滋病患者和有患艾滋病风险的人群中频繁检测和分离出细胞病变逆转录病毒（HTLV-III）。
Science. 1984 May 4;224(4648):500-3. doi: 10.1126/science.6200936.
4
Prevalence of antibody to human T-lymphotropic virus type III in AIDS and AIDS-risk patients in Britain.英国艾滋病患者及艾滋病高危人群中抗人类Ⅲ型嗜T淋巴细胞病毒抗体的流行情况。
Lancet. 1984 Sep 1;2(8401):477-80. doi: 10.1016/s0140-6736(84)92562-5.
5
Low prevalence in the UK of HTLV-I and HTLV-II infection in subjects with AIDS, with extended lymphadenopathy, and at risk of AIDS.在英国，艾滋病患者、有广泛性淋巴结病的人群以及有艾滋病风险的人群中，人类嗜T淋巴细胞病毒I型（HTLV-I）和人类嗜T淋巴细胞病毒II型（HTLV-II）感染的患病率较低。
Lancet. 1984 Jul 21;2(8395):125-8. doi: 10.1016/s0140-6736(84)91046-8.
6
Seroconversion of human T cell lymphotrophic virus III (HTLV-III) in patients with haemophilia: a longitudinal study.血友病患者中人类嗜T淋巴细胞病毒III型（HTLV-III）的血清转化：一项纵向研究。
Br Med J (Clin Res Ed). 1985 Jun 8;290(6483):1705-6. doi: 10.1136/bmj.290.6483.1705-a.
7
Prevalence of antibody to human T lymphotropic virus type III by risk group and area, United Kingdom 1978-84.1978 - 1984年英国按风险组和地区划分的人类嗜T淋巴细胞病毒III型抗体流行率。
Br Med J (Clin Res Ed). 1985 Apr 20;290(6476):1176-8. doi: 10.1136/bmj.290.6476.1176.
8
Are homosexuals less at risk of AIDS than intravenous drug abusers and haemophiliacs?同性恋者感染艾滋病的风险是否比静脉注射吸毒者和血友病患者更低？
Lancet. 1985 Nov 16;2(8464):1130. doi: 10.1016/s0140-6736(85)90722-6.
9
Human T-lymphotropic virus type III (HTLV-III) infection in seronegative haemophiliacs after transfusion of factor VIII.输血后血清反应阴性血友病患者的人嗜T淋巴细胞病毒III型（HTLV-III）感染
Lancet. 1985 Aug 3;2(8449):233-6. doi: 10.1016/s0140-6736(85)90288-0.
10
Rising prevalence of human T-lymphotropic virus type III (HTLV-III) infection in homosexual men in London.伦敦同性恋男性中人类嗜T淋巴细胞病毒III型（HTLV-III）感染率上升。
Lancet. 1985 Jun 1;1(8440):1261-2. doi: 10.1016/s0140-6736(85)92324-4.

在英国接受各种凝血因子治疗的患者中发生的逆转录病毒感染。

Retrovirus infections among patients treated in Britain with various clotting factors.

作者信息

Cheinsong-Popov R, Tedder R S, O'Connor T, Clayden S, Smith A, Craske J, Weiss R

出版信息

Br Med J (Clin Res Ed). 1986 Jul 19;293(6540):168-9. doi: 10.1136/bmj.293.6540.168.

DOI:10.1136/bmj.293.6540.168
PMID:3015319
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1340907/
Abstract

At the end of 1984 a collaborative survey was carried out to determine the prevalence of infection with human T cell lymphotropic virus type III/lymphadenopathy associated virus (HTLV-III/LAV) and HTLV-I among 584 recipients of various blood products in Britain at that time. In 204 cases yearly point prevalence figures for infection were also obtained for 1978 to 1983. In 1984, 215 of 315 patients (68%) who had received commercial concentrate for haemophilia A were identified as positive for anti-HTLV-III/LAV as compared with only 18 of 166 patients (11%) given British concentrate alone for this disease. This difference was further emphasised by the yearly point prevalence rates: seroconversion began in 1980 among recipients of commercial concentrate, but not until 1983 did such an instance occur among recipients of British concentrate. Any conclusions must remain speculative, but possibly seropositivity among haemophiliacs may not carry so grave a prognosis as previously thought.

摘要

1984年底开展了一项合作调查，以确定当时英国584名各类血液制品接受者中人类嗜T细胞病毒III型/淋巴结病相关病毒（HTLV-III/LAV）和HTLV-I的感染率。对于其中204例病例，还获取了1978年至1983年的年度感染点患病率数据。1984年，接受商业性甲型血友病浓缩制剂的315名患者中有215名（68%）被确定为抗HTLV-III/LAV阳性，而仅接受英国产浓缩制剂治疗该疾病的166名患者中只有18名（11%）呈阳性。年度感染点患病率进一步凸显了这种差异：商业浓缩制剂接受者中血清转化始于1980年，而英国浓缩制剂接受者直到1983年才出现血清转化情况。任何结论都只能是推测性的，但血友病患者的血清阳性预后可能不像之前认为的那么严重。