Çalışır Metin, Akpınar Aysun, Talmaç Ahmet Cemil, Lektemur Alpan Aysan, Göze Ömer Fahrettin
Department of Periodontology, Faculty of Dentistry, Adiyaman University, Adiyaman, Turkey.
Department of Periodontology, Faculty of Dentistry, Cumhuriyet University, Sivas, Turkey.
Evid Based Complement Alternat Med. 2018 Aug 1;2018:1783513. doi: 10.1155/2018/1783513. eCollection 2018.
Humic acid was previously shown to enhance cutaneous wound healing and show antibacterial properties; however, it has not been used for wound healing in the oral cavity. Thus, the goal of this study was the evaluation of the effect of the humic acid on the healing of excisional wounds in an experimental rat study.
A circular wound on mid-palatal surfaces was made on a total of 77 Wistar rats by using a 3-mm biopsy punch under anesthesia. The animals were divided into 4 groups as baseline, saline control (0.09%), chlorhexidine gluconate (0.05%), and humic acid (80 mg/kg) and were treated with these materials for 7 days.
The rats were observed for 3 weeks in order to track the wound closure rates. Both humic acid treatment and chlorhexidine gluconate treatment resulted in statistically significant enhanced rate of wound closure compared to the saline control on both the 1st and 2nd weeks of treatment. Humic acid treatment for the wounds in the palate resulted in enhanced recovery compared to not only saline control but also chlorhexidine gluconate treatment.
In this study, humic acid was shown to enhance healing of oral wounds for the first time in the literature. These findings indicate that humic acid can be used as an alternative to current treatment methods for oral wounds.
腐殖酸先前已被证明可促进皮肤伤口愈合并具有抗菌特性；然而，它尚未用于口腔伤口愈合。因此，本研究的目的是在一项实验性大鼠研究中评估腐殖酸对切除伤口愈合的影响。
在麻醉下，使用3毫米活检打孔器在总共77只Wistar大鼠的腭中表面制作圆形伤口。将动物分为4组，即基线组、生理盐水对照组（0.09%）、葡萄糖酸氯己定组（0.05%）和腐殖酸组（80毫克/千克），并用这些材料治疗7天。
观察大鼠3周以跟踪伤口闭合率。在治疗的第1周和第2周，腐殖酸治疗和葡萄糖酸氯己定治疗与生理盐水对照组相比，均导致伤口闭合率在统计学上显著提高。腭部伤口的腐殖酸治疗不仅与生理盐水对照组相比，而且与葡萄糖酸氯己定治疗相比，均导致恢复增强。
在本研究中，腐殖酸在文献中首次被证明可促进口腔伤口愈合。这些发现表明，腐殖酸可作为口腔伤口当前治疗方法的替代物。
