胸腺移植嵌合体中对非胸腺亲本H-2单倍型特异的T细胞的抑制
Suppression of T cells specific for the nonthymic parental H-2 haplotype in thymus-grafted chimeras.
作者信息
Smith F I, Miller J F
出版信息
J Exp Med. 1980 Jan 1;151(1):246-51. doi: 10.1084/jem.151.1.246.
Abstract
The mechanism of restriction of T-cell specificity by the genotype of the thymus in allogeneic and semiallogeneic chimeras was investigated. Lack of induction of delayed-type hypersensitivity (DTH) directed against antigen in association with the nonthymic parental haplotype in naive cells adoptively transferred into chimeras suggests the existence of an in vivo suppressive mechanism. However, it was not possible to suppress the expression of DTH in sensitized cells transferred into chimeras, or to transfer this suppression to normal naive recipients.
摘要
研究了在同种异体和半同种异体嵌合体中胸腺基因型对T细胞特异性的限制机制。将幼稚细胞过继转移到嵌合体中后，缺乏针对与非胸腺亲本单倍型相关抗原的迟发型超敏反应（DTH）诱导，这表明存在一种体内抑制机制。然而，无法抑制转移到嵌合体中的致敏细胞中DTH的表达，也无法将这种抑制作用转移给正常的幼稚受体。
相似文献
1
Suppression of T cells specific for the nonthymic parental H-2 haplotype in thymus-grafted chimeras.胸腺移植嵌合体中对非胸腺亲本H-2单倍型特异的T细胞的抑制
J Exp Med. 1980 Jan 1;151(1):246-51. doi: 10.1084/jem.151.1.246.
2
Immune responses of thymus/lymphocyte embryonic chimeras: studies on tolerance and major histocompatibility complex restriction in Xenopus.胸腺/淋巴细胞胚胎嵌合体的免疫反应：非洲爪蟾中耐受性和主要组织相容性复合体限制的研究
Eur J Immunol. 1985 Jun;15(6):540-7. doi: 10.1002/eji.1830150603.
3
Bone marrow-derived thymic antigen-presenting cells determine self-recognition of Ia-restricted T lymphocytes.骨髓来源的胸腺抗原呈递细胞决定了Ia限制型T淋巴细胞的自身识别。
Proc Natl Acad Sci U S A. 1985 Sep;82(17):5900-4. doi: 10.1073/pnas.82.17.5900.
4
H-2 antigens of the thymus determine lymphocyte specificity.胸腺的H-2抗原决定淋巴细胞特异性。
J Exp Med. 1978 Sep 1;148(3):766-75. doi: 10.1084/jem.148.3.766.
5
Role of major histocompatibility complex gene products in delayed-type hypersensitivity.主要组织相容性复合体基因产物在迟发型超敏反应中的作用。
Proc Natl Acad Sci U S A. 1976 Jul;73(7):2486-90. doi: 10.1073/pnas.73.7.2486.
6
Thymic reconstitution of nude F1 mice with one or both parental thymus grafts.用一个或两个亲代胸腺移植物对裸F1小鼠进行胸腺重建。
J Exp Med. 1979 Sep 19;150(3):693-7. doi: 10.1084/jem.150.3.693.
7
8
Influence of thymus genotype on acquisition of responsiveness in delayed-type hypersensitivity.胸腺基因型对迟发型超敏反应中反应性获得的影响。
Scand J Immunol. 1979;9(1):29-38. doi: 10.1111/j.1365-3083.1979.tb02703.x.
9
Influence of H-2 antigen expression on killer T cell specificity, differentiation, and induction.H-2抗原表达对杀伤性T细胞特异性、分化及诱导的影响。
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6401-5. doi: 10.1073/pnas.78.10.6401.
引用本文的文献
1
Restricted antibody formation to sheep erythrocytes of allogeneic bone marrow chimeras histoincompatible at the K end of the H-2 complex.在H-2复合体K端组织不相容的同种异体骨髓嵌合体中，针对绵羊红细胞的抗体形成受到限制。
J Exp Med. 1981 Apr 1;153(4):1009-14. doi: 10.1084/jem.153.4.1009.
2
T cell recognition of antigen in vivo: role of the H-2 complex.体内T细胞对抗原的识别：H-2复合体的作用。
Springer Semin Immunopathol. 1980 Aug;3(2):213-45. doi: 10.1007/BF02053976.
3
Frequency analysis of cytotoxic T lymphocyte precursors in chimeric mice. Evidence for intrathymic maturation of clonally distinct self-major histocompatibility complex- and allo-major histocompatiblilty complex-restricted virus-specific T cells.嵌合小鼠中细胞毒性T淋巴细胞前体的频率分析。克隆性不同的自身主要组织相容性复合体和同种异体主要组织相容性复合体限制性病毒特异性T细胞胸腺内成熟的证据。
J Exp Med. 1981 Jun 1;153(6):1517-32. doi: 10.1084/jem.153.6.1517.
4
Sendai virus-specific, H-2-restricted cytotoxic T lymphocyte responses of nude mice grafted with allogeneic or semi-allogeneic thymus glands.接种了同种异体或半同种异体胸腺的裸鼠对仙台病毒特异性、H-2限制的细胞毒性T淋巴细胞反应
J Exp Med. 1980 Dec 1;152(6):1805-10. doi: 10.1084/jem.152.6.1805.
5
Immunoreactivity of long lived H-2 incompatible irradiation chimeras (H-2d leads to H-2b).长寿的H-2不相容辐射嵌合体（H-2d到H-2b）的免疫反应性
Immunology. 1982 Jun;46(2):253-60.
6
Role of the major histocompatibility gene products in regulating the antibody response to dinitrophenylated poly(L-Glu55,L-Ala35,L-Phe9)n.主要组织相容性基因产物在调节对二硝基苯基化聚（L-谷氨酸55、L-丙氨酸35、L-苯丙氨酸9）n的抗体应答中的作用。
J Exp Med. 1980 Aug 1;152(2):336-49. doi: 10.1084/jem.152.2.336.
7
Bone marrow-derived thymic antigen-presenting cells determine self-recognition of Ia-restricted T lymphocytes.骨髓来源的胸腺抗原呈递细胞决定了Ia限制型T淋巴细胞的自身识别。
Proc Natl Acad Sci U S A. 1985 Sep;82(17):5900-4. doi: 10.1073/pnas.82.17.5900.
8
Positive selection determines T cell receptor V beta 14 gene usage by CD8+ T cells.阳性选择决定CD8⁺T细胞对T细胞受体Vβ14基因的使用。
J Exp Med. 1989 Jul 1;170(1):135-43. doi: 10.1084/jem.170.1.135.
本文引用的文献
1
The function and interrelationships of T-cell receptors, Ir genes and other histocompatibility gene products.T细胞受体、免疫反应基因及其他组织相容性基因产物的功能与相互关系。
Transplant Rev. 1975;22:175-95. doi: 10.1111/j.1600-065x.1975.tb01559.x.
2
Vaccinia-specific cytotoxic T-cell responses in the context of H-2 antigens not encountered in thymus may reflect aberrant recognition of a virus-H-2 complex.在胸腺中未遇到的H-2抗原背景下，牛痘特异性细胞毒性T细胞反应可能反映了对病毒-H-2复合物的异常识别。
J Exp Med. 1979 Jan 1;149(1):150-7. doi: 10.1084/jem.149.1.150.
3
H-2 antigens of the thymus determine lymphocyte specificity.胸腺的H-2抗原决定淋巴细胞特异性。
J Exp Med. 1978 Sep 1;148(3):766-75. doi: 10.1084/jem.148.3.766.
4
Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.主要组织相容性复合体相关的免疫反应性是由低反应性小鼠的淋巴细胞在高反应性小鼠的胸腺中分化而获得的。
Proc Natl Acad Sci U S A. 1978 May;75(5):2439-42. doi: 10.1073/pnas.75.5.2439.
5
6
T cells specific for hapten-modified self are precommitted for self major histocompatibility complex antigens before encounter with the hapten.对半抗原修饰自身具有特异性的T细胞在遇到半抗原之前就已预先倾向于自身主要组织相容性复合体抗原。
J Exp Med. 1978 Apr 1;147(4):1065-77. doi: 10.1084/jem.147.4.1065.
7
The generation of killer cells to trinitrophenyl-modified allogeneic targets by lymphocyte populations negatively selected to strong alloantigens.通过对强同种抗原进行阴性选择的淋巴细胞群体产生针对三硝基苯基修饰的同种异体靶标的杀伤细胞。
J Exp Med. 1977 Aug 1;146(2):361-7. doi: 10.1084/jem.146.2.361.
8
9
Influence of thymus genotype on acquisition of responsiveness in delayed-type hypersensitivity.胸腺基因型对迟发型超敏反应中反应性获得的影响。
Scand J Immunol. 1979;9(1):29-38. doi: 10.1111/j.1365-3083.1979.tb02703.x.
10
I-region-coded products expressed on both macrophages and thymus epithelium influence T-cell activities.在巨噬细胞和胸腺上皮细胞上表达的I区编码产物会影响T细胞的活性。
Scand J Immunol. 1979;10(4):343-7. doi: 10.1111/j.1365-3083.1979.tb01361.x.
Zotero 插件