Rosenzweig Adam, Blenis John, Gomes Ana P
Meyer Cancer Center, Weill Cornell Medicine, New York, NY, United States.
Department of Pharmacology, Weill Cornell Medicine, New York, NY, United States.
Front Cell Dev Biol. 2018 Aug 15;6:90. doi: 10.3389/fcell.2018.00090. eCollection 2018.
Altered metabolism in cancer cells is critical for tumor growth. One of the most notable aspects of this metabolic reprogramming lies in one-carbon metabolism. Cells require one-carbon units for nucleotide synthesis, methylation reactions, and for the generation of reducing cofactors. Therefore, the ability to rewire and fine-tune one-carbon metabolism is essential for the maintenance of cellular homeostasis. In this review, we describe how the major nutrient, energy, and redox sensors of the cell play a significant role in the regulation of flux through one-carbon metabolism to enable cell fate decisions. We will also discuss how dysregulated oncogenic signaling hijacks these regulatory mechanisms to support and sustain high rates of proliferation and cell survival essential for tumor growth.
癌细胞代谢的改变对肿瘤生长至关重要。这种代谢重编程最显著的一个方面在于一碳代谢。细胞需要一碳单位用于核苷酸合成、甲基化反应以及还原型辅因子的生成。因此，重新连接和微调一碳代谢的能力对于维持细胞内稳态至关重要。在这篇综述中，我们描述了细胞的主要营养、能量和氧化还原传感器如何在调节一碳代谢通量以促成细胞命运决定方面发挥重要作用。我们还将讨论失调的致癌信号如何劫持这些调节机制以支持和维持肿瘤生长所必需的高增殖率和细胞存活。
