通过酶联免疫吸附测定（ELISA）检测的BK病毒IgG和IgM抗体的年龄依赖性流行率。
Age-dependent prevalence of BK virus IgG and IgM antibodies measured by enzyme-linked immunosorbent assays (ELISA).
作者信息
Flaegstad T, Traavik T, Kristiansen B E
出版信息
J Hyg (Lond). 1986 Jun;96(3):523-8. doi: 10.1017/s0022172400066328.
Abstract
Enzyme immunoassays (ELISA) have been developed for the detection of BK virus IgG- and IgM-antibodies. Specific IgG is detected by an antigen-coated solid phase test; IgM by an antibody capture method. These methods have been used to study the age-distribution of BK virus antibodies in Tromsø county in Northern Norway. The serum panels tested were: 60 sera from paediatric patients aged 0-1 year; 220 sera from healthy persons aged 1-82 years; 74 sera from healthy blood donors; 107 sera from healthy pregnant women. The age-distribution of BKV-IgG antibodies showed that primary infections took place predominantly between the ages of 1 and 6 years, and that there were no sex differences, either in the age-specific prevalence or in the level of BKV-IgG. We found no significant differences in the prevalence of BKV-IgM antibodies in healthy children and adults and pregnant women. BKV-IgM was detected in 26 of the 461 sera tested (5.6%).
摘要
已经开发出酶免疫测定法（ELISA）用于检测BK病毒IgG和IgM抗体。通过抗原包被的固相试验检测特异性IgG；通过抗体捕获法检测IgM。这些方法已用于研究挪威北部特罗姆瑟郡BK病毒抗体的年龄分布。所检测的血清样本包括：60份来自0至1岁儿科患者的血清；220份来自1至82岁健康人的血清；74份来自健康献血者的血清；107份来自健康孕妇的血清。BKV-IgG抗体的年龄分布表明，初次感染主要发生在1至6岁之间，并且在年龄特异性患病率或BKV-IgG水平方面没有性别差异。我们发现健康儿童、成人和孕妇中BKV-IgM抗体的患病率没有显著差异。在所检测的461份血清中有26份（5.6%）检测到BKV-IgM。
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本文引用的文献
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Prevalence in England of antibody to human polyomavirus (B.k.).英国人群中人类多瘤病毒（BK）抗体的流行率。
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Serological investigation of BK papovavirus infection in pregnant women and their offspring.孕妇及其后代BK多瘤病毒感染的血清学调查。
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BK virus specific IgM responses in cord sera, young children and healthy adults detected by RIA.用放射免疫分析法检测脐带血清、幼儿和健康成年人中BK病毒特异性IgM反应。
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Detection of BK virus IgM antibodies by two enzyme-linked immunosorbent assays (ELISA) and a hemagglutination inhibition method.通过两种酶联免疫吸附测定法（ELISA）和血凝抑制法检测BK病毒IgM抗体。
J Med Virol. 1985 Oct;17(2):195-204. doi: 10.1002/jmv.1890170212.
10
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J Med Virol. 1985 Aug;16(4):351-6. doi: 10.1002/jmv.1890160408.
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