Jezek Z, Marennikova S S, Mutumbo M, Nakano J H, Paluku K M, Szczeniowski M
J Infect Dis. 1986 Oct;154(4):551-5. doi: 10.1093/infdis/154.4.551.
A study of 2,510 contacts of 214 patients with human monkeypox was conducted in Zaire from 1980 to 1984. Among the contacts of 130 primary cases of human monkeypox, a further 22 co-primary and 62 secondary cases were detected, and an additional fourteen people who had no evidence of clinical disease had positive serological results. A majority of the clinical and subclinical cases of monkeypox occurred in children less than 10 years of age. Immunity in vaccinated persons now appears to be waning because 16 overt cases occurred in contacts who had been vaccinated. The overall attack rate for contacts without a vaccination scar (7.2%) differed significantly from the attack rate for those who had been vaccinated in the past (0.9%). The attack rate for household contacts was significantly higher than that for other contacts, among both unvaccinated (four times higher) and vaccinated (seven times higher) household contacts. Many unvaccinated contacts living in the same household as the index case under conditions of maximum exposure, however, escaped not only the disease but also infection.
1980年至1984年期间，在扎伊尔对214例人类猴痘患者的2510名接触者进行了一项研究。在130例人类猴痘原发病例的接触者中，又检测出22例共同原发病例和62例继发病例，另有14名无临床疾病证据的人血清学检测呈阳性。大多数猴痘临床和亚临床病例发生在10岁以下儿童中。由于在已接种疫苗的接触者中出现了16例显性病例，目前看来接种疫苗者的免疫力正在下降。无接种疤痕接触者的总体发病率（7.2%）与过去接种过疫苗者的发病率（0.9%）有显著差异。在未接种疫苗（高四倍）和接种过疫苗（高七倍）的家庭接触者中，家庭接触者的发病率均显著高于其他接触者。然而，许多在最大暴露条件下与索引病例居住在同一家庭的未接种疫苗接触者不仅逃过了疾病，也逃过了感染。
