通过细胞分裂素和 SPEECHLESS 调节相互作用对拟南芥气孔谱系中不对称分裂多样性的调控。
Modulation of Asymmetric Division Diversity through Cytokinin and SPEECHLESS Regulatory Interactions in the Arabidopsis Stomatal Lineage.
机构信息
Department of Biology, Stanford University, Stanford, CA 94305-5020, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305-5020, USA.
Department of Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA.
出版信息
Dev Cell. 2018 Oct 8;47(1):53-66.e5. doi: 10.1016/j.devcel.2018.08.007. Epub 2018 Sep 6.
Coordinated growth of organs requires communication among cells within and between tissues. In plants, leaf growth is largely dictated by the epidermis; here, asymmetric and self-renewing divisions of the stomatal lineage create two essential cell types-pavement cells and guard cells-in proportions reflecting inputs from local, systemic, and environmental cues. The transcription factor SPEECHLESS (SPCH) is the prime regulator of divisions, but whether and how it is influenced by external cues to provide flexible development is enigmatic. Here, we show that the phytohormone cytokinin (CK) can act as an endogenous signal to affect the extent and types of stomatal lineage divisions and forms a regulatory circuit with SPCH. Local domains of low CK signaling are created by SPCH-dependent cell-type-specific activity of two repressive type-A ARABIDOPSIS RESPONSE REGULATORs (ARRs), ARR16 and ARR17, and two secreted peptides, CLE9 and CLE10, which, together with SPCH, can customize epidermal cell-type composition.
器官的协调生长需要细胞在组织内和组织间进行通讯。在植物中，叶片生长主要由表皮决定；在这里，气孔谱系的不对称和自我更新分裂产生了两种必需的细胞类型——叶表皮细胞和保卫细胞——其比例反映了来自局部、系统和环境线索的输入。转录因子 SPEECHLESS (SPCH) 是分裂的主要调节因子，但它是否以及如何受到外部线索的影响以提供灵活的发育仍然是个谜。在这里，我们表明，植物激素细胞分裂素 (CK) 可以作为内源性信号来影响气孔谱系分裂的程度和类型，并与 SPCH 形成一个调节回路。低 CK 信号的局部区域是由 SPCH 依赖性的两个抑制型 TYPE-A ARABIDOPSIS RESPONSE REGULATORs (ARRs)，ARR16 和 ARR17，以及两个分泌肽 CLE9 和 CLE10 的细胞类型特异性活性产生的，它们与 SPCH 一起，可以定制表皮细胞类型组成。
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