Taherian Reza, Jalali-Farahani Sara, Karimi Mehrdad, Amiri Parisa, Maghsoudi Emad, Mirmiran Parvin, Azizi Fereidoun
Research Center for Social Determinants of Health, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Int J Endocrinol Metab. 2018 Jun 29;16(3):e59706. doi: 10.5812/ijem.59706. eCollection 2018 Jul.
Pre-hypertension is proposed as an independent risk factor for the incidence of cardiovascular diseases.
This study aimed to explore the main factors associated with pre-hypertension via testing a hypothesized model in Tehranian adults.
The study was conducted within the framework of the Tehran Lipid and Glucose Study (TLGS) between 2009 - 2011 on 4640 adults without hypertension, aged ≥ 20 years.
The mean age of participants was 38.61 ± 12.14 years and 56.6% of them were female. More than one third of the studied participants had pre-hypertension (35.4%) with significantly higher prevalence in males compared to females (46.5% vs. 26.9%; χ = 190.7, P < 0.001). Age, waist circumference (WC), and serum triglyceride concentrations (TG) were directly associated with pre-hypertension in both men (β = 0.16, β = 0.25, and β = 0.11, respectively) and women (β = 0.16, β = 0.21 and β = 0.09, respectively). Physical activity, only in men (β = 0.07), and marital status only, in women (β = -0.06), were also directly associated with pre-hypertension. Both healthy and poor dietary patterns showed indirect associations with pre-hypertension in both genders via WC and TG. Higher age and lower education in both genders, being married only in men, and unemployed status only in women, were positively associated with pre-hypertension via behavioral and cardio-metabolic factors.
Level of TG and WC in both genders are direct modifiable associated factors of pre-hypertension. These findings could be considered in designing future health promotion programs aimed at preventing high blood pressure and its consequences among Tehranian adults.
高血压前期被认为是心血管疾病发病的独立危险因素。
本研究旨在通过在德黑兰成年人中测试一个假设模型，探索与高血压前期相关的主要因素。
本研究于2009年至2011年在德黑兰血脂与血糖研究（TLGS）框架内，对4640名年龄≥20岁的无高血压成年人进行。
参与者的平均年龄为38.61±12.14岁，其中56.6%为女性。超过三分之一的研究参与者患有高血压前期（35.4%），男性患病率显著高于女性（46.5%对26.9%；χ = 190.7，P < 0.001）。年龄、腰围（WC）和血清甘油三酯浓度（TG）在男性（β分别为0.16、0.25和0.11）和女性（β分别为0.16、0.21和0.09）中均与高血压前期直接相关。体育活动仅在男性中（β = 0.07）以及婚姻状况仅在女性中（β = -0.06）也与高血压前期直接相关。健康和不良饮食模式在两性中均通过WC和TG与高血压前期存在间接关联。较高年龄和较低教育水平在两性中、仅男性已婚以及仅女性失业状态通过行为和心血管代谢因素与高血压前期呈正相关。
两性中TG水平和WC是高血压前期直接可改变的相关因素。在设计未来旨在预防德黑兰成年人高血压及其后果的健康促进项目时，可考虑这些发现。
