Cannino Giuseppe, Ciscato Francesco, Masgras Ionica, Sánchez-Martín Carlos, Rasola Andrea
Department of Biomedical Sciences, University of Padova, Padova, Italy.
Front Oncol. 2018 Aug 24;8:333. doi: 10.3389/fonc.2018.00333. eCollection 2018.
Mitochondria are dynamic organelles that exchange a multiplicity of signals with other cell compartments, in order to finely adjust key biological routines to the fluctuating metabolic needs of the cell. During neoplastic transformation, cells must provide an adequate supply of the anabolic building blocks required to meet a relentless proliferation pressure. This can occur in conditions of inconstant blood perfusion leading to variations in oxygen and nutrient levels. Mitochondria afford the bioenergetic plasticity that allows tumor cells to adapt and thrive in this ever changing and often unfavorable environment. Here we analyse how mitochondria orchestrate the profound metabolic rewiring required for neoplastic growth.
线粒体是动态细胞器，可与细胞内其他区室交换多种信号，以便根据细胞波动的代谢需求精确调整关键生物学过程。在肿瘤转化过程中，细胞必须提供足够的合成代谢构件供应，以应对持续不断的增殖压力。这可能发生在血液灌注不稳定导致氧气和营养水平变化的情况下。线粒体具有生物能量可塑性，使肿瘤细胞能够在这种不断变化且通常不利的环境中适应并茁壮成长。在此，我们分析线粒体如何协调肿瘤生长所需的深刻代谢重编程。
