Jiang Li-Ning, Liu Ya-Bin, Li Bing-Hui
Department of Surgery II, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China Department of Urology Surgery I, Cangzhou Central Hospital, Cangzhou 061000, China.
Asian J Androl. 2019 Jan 1;21(1):80-85. doi: 10.4103/aja.aja_70_18.
Lycopene is a natural compound that alleviates oxidative stress and inflammation, exerting therapeutic effects in a number of cancers. The aim of this study is to investigate the efficacy of lycopene in inhibiting prostate cancer. Cell viability assays indicated the dose- and time-dependent toxicity of lycopene in prostate cancer cells. Annexin V/propidium iodide double-staining assays revealed the strong apoptotic effects of lycopene. The levels of inflammatory factors, including interleukin-1 (IL1), IL6, IL8, and tumor necrosis factor-α (TNF-α), in lycopene-treated cells were also reduced by lycopene treatment. With the increasing dose of lycopene, the survival of mice bearing prostate cancer xenografts was significantly improved ( P < 0.01), and the tumor burden was significantly reduced ( P < 0.01). Our results indicate that lycopene is a promising chemotherapy drug, which inhibits prostate cancer progression by suppressing the inflammatory response.
番茄红素是一种天然化合物，可减轻氧化应激和炎症，对多种癌症具有治疗作用。本研究的目的是探讨番茄红素抑制前列腺癌的疗效。细胞活力测定表明番茄红素对前列腺癌细胞具有剂量和时间依赖性毒性。膜联蛋白V/碘化丙啶双染色测定显示番茄红素具有很强的凋亡作用。番茄红素处理还降低了番茄红素处理细胞中包括白细胞介素-1（IL1）、IL6、IL8和肿瘤坏死因子-α（TNF-α）在内的炎症因子水平。随着番茄红素剂量的增加，携带前列腺癌异种移植物的小鼠存活率显著提高（P<0.01），肿瘤负荷显著降低（P<0.01）。我们的结果表明，番茄红素是一种有前景的化疗药物，它通过抑制炎症反应来抑制前列腺癌进展。
