Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
Department of Chemistry, University of British Columbia, Vancouver, BC V6T1Z1, Canada.
Mar Drugs. 2018 Sep 11;16(9):326. doi: 10.3390/md16090326.
Seven long-chain amides, including five previously undescribed bacillamidins A⁻E (⁻) and two previously reported synthetic analogs, bacillamidins F () and G (), were isolated from extracts of the marine-derived strain RJA1515. The structures of the new compounds were established by extensive analysis of 1D and 2D nuclear magnetic resonance (NMR) data as well as high resolution mass spectrometry (HRMS), and the absolute configurations of the stereogenic carbons of ⁻ were established by comparison of the calculated and the experimental electronic circular dichroism (ECD) spectra. The cytotoxic and antimicrobial activities of ⁻ were evaluated.
从海洋来源的 菌株 RJA1515 的提取物中分离得到了七种长链酰胺，包括五种以前未描述的杆菌霉素 A⁻E（⁻）和两种以前报道的合成类似物，杆菌霉素 F（）和 G（）。通过对 1D 和 2D 核磁共振（NMR）数据以及高分辨率质谱（HRMS）的广泛分析，确定了新化合物的结构，并通过比较计算和实验电子圆二色性（ECD）光谱确定了 ⁻ 中立体碳原子的绝对构型。评估了 ⁻ 的细胞毒性和抗菌活性。
