人类类带3基因在染色体上定位于7q35至7q36区域。

Palumbo A P, Isobe M, Huebner K, Shane S, Rovera G, Demuth D, Curtis P J, Ballantine M, Croce C M, Showe L C

Am J Hum Genet. 1986 Sep;39(3):307-16.

Band 3, the major transmembrane protein of erythrocytes, mediates the exchange of anions across the membrane and anchors the erythroid membrane skeleton. Proteins immunologically related to Band 3 have been detected in a variety of nonerythroid cells. We have isolated a human cDNA clone that encodes a protein related to but distinct from the erythroid form of Band 3, based on the comparison of the amino acid sequence for the two proteins. The presence of the gene for the Band 3-like protein in a panel of mouse-human somatic cell hybrids containing subsets of human chromosomes correlated with the presence of human chromosome 7. In situ hybridization analysis using the c-DNA for this nonerythroid Band 3 gene further localized the gene to region 7q35----7q36 of human metaphase chromosomes.

带3是红细胞的主要跨膜蛋白，介导阴离子跨膜交换并锚定红细胞膜骨架。在多种非红细胞中已检测到与带3免疫相关的蛋白质。基于两种蛋白质氨基酸序列的比较，我们分离出了一个人类cDNA克隆，该克隆编码一种与红细胞形式的带3相关但又不同的蛋白质。在一组包含人类染色体亚群的小鼠-人类体细胞杂种中，类带3蛋白基因的存在与人类染色体7的存在相关。使用该非红细胞带3基因的cDNA进行原位杂交分析，进一步将该基因定位到人类中期染色体的7q35----7q36区域。