1984 - 1986年英格兰和威尔士脊髓灰质炎病毒抗体的流行情况
Prevalence of antibody to poliovirus in England and Wales 1984-6.
作者信息
White P M, Green J
出版信息
Br Med J (Clin Res Ed). 1986 Nov 1;293(6555):1153-5. doi: 10.1136/bmj.293.6555.1153.
Abstract
Serum from 995 subjects aged 6 months to 99 years was screened at a dilution of 1/8 for neutralising antibodies to poliovirus. Of these samples, 975 (98%) contained antibody to at least one serotype, and 763 (77%) contained antibody to all three, an improvement since previous studies. Children aged 8 to 15, however, had a low prevalence of antibody to poliovirus type 3, with only four (40%) of those aged 12 protected. This finding is possibly due to the waning of antibodies induced by the type 3 component of oral poliovirus vaccine and emphasises the continued importance of a booster dose of vaccine for those leaving school.
摘要
对995名年龄在6个月至99岁之间的受试者的血清进行了检测，以1/8的稀释度筛查针对脊髓灰质炎病毒的中和抗体。在这些样本中，975份（98%）含有针对至少一种血清型的抗体，763份（77%）含有针对所有三种血清型的抗体，这是自先前研究以来的一项进步。然而，8至15岁的儿童中，脊髓灰质炎3型抗体的流行率较低，12岁的儿童中只有4名（40%）受到保护。这一发现可能是由于口服脊髓灰质炎疫苗3型成分诱导的抗体逐渐减少，强调了对离校者进行疫苗加强剂量接种的持续重要性。
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