Gao Zhe, Hadipour Moghaddam Seyyed Pouya, Ghandehari Hamidreza, Zharov Ilya
Department of Chemistry, University of Utah, Salt Lake City, UT 84112, USA.
Department of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, University of Utah.
RSC Adv. 2018;8(9):4914-4920. doi: 10.1039/C7RA12377A. Epub 2018 Jan 29.
Silica nanoparticles (SNPs) are attractive for applications for the delivery of drugs and as imaging agents due to their ease of synthesis and scale up, robust structure, and controllable size and composition. Degradability is one important factor that limits biomedical applications of SNPs. With this in mind, we designed, prepared and characterized novel hydrolysable organosilica nanoparticles (ICPTES-Sorbitol SNPs). These particles were prepared by co-condensation of tetraethoxysilane with a bridged sorbitol-based silsesquioxane precursor containing carbamate linkages. The non-porous spherical ICPTES-Sorbitol SNPs became porous after they were placed in an aqueous environment as a result of the hydrolysis of carbamate bonds and were completely degraded upon prolonged exposure to water. The rate of degradation depended on the pH of the solution, with nanoparticles degrading slower at pH 2 than at pH 4 or pH 7. The degradation was demonstrated by transmission electron microscopy, nitrogen desorption analysis and solution analytical techniques such as ICP-MS and molybdenum blue assay, which was also used to follow the dissolution of ICPTES-Sorbitol SNPs.
由于易于合成和放大、结构坚固以及尺寸和组成可控，二氧化硅纳米颗粒（SNPs）在药物递送和作为成像剂的应用中具有吸引力。可降解性是限制SNPs生物医学应用的一个重要因素。考虑到这一点，我们设计、制备并表征了新型可水解有机硅纳米颗粒（ICPTES-山梨醇SNPs）。这些颗粒是通过四乙氧基硅烷与含有氨基甲酸酯键的桥连山梨醇基倍半硅氧烷前体共缩合制备的。无孔球形ICPTES-山梨醇SNPs在置于水性环境中后，由于氨基甲酸酯键的水解而变成多孔，并在长时间暴露于水后完全降解。降解速率取决于溶液的pH值，纳米颗粒在pH 2时的降解速度比在pH 4或pH 7时慢。通过透射电子显微镜、氮解吸分析以及ICP-MS和钼蓝测定等溶液分析技术证明了降解，这些技术也用于跟踪ICPTES-山梨醇SNPs的溶解情况。
