Department of Toxicology, Medical University of Bialystok, Adama Mickiewicza 2C Street, 15-222, Bialystok, Poland.
J Appl Toxicol. 2019 Jan;39(1):117-145. doi: 10.1002/jat.3709. Epub 2018 Sep 14.
Recently, the growing attention of the scientific community has been focused on the threat to health created by environmental pollutants, including toxic metals such as cadmium (Cd), and on the need of finding effective ways to prevent and treat the unfavorable health effects of exposure to them. Particularly promising for Cd, and thus arousing the greatest interest, is the possibility of using various ingredients present in plants, including mainly polyphenolic compounds. As the liver is one of the target organs for this toxic metal and disturbances in the proper functioning of this organ have serious consequences for health, the aim of the present review was to discuss the possibility of using polyphenol-rich food products (e.g., chokeberry, black and green tea, blueberry, olive oil, rosemary and ginger) as the strategy in protection from this xenobiotic hepatotoxicity and treatment of this heavy metal-induced liver damage. Owing to the ability of polyphenols to bind ions of Cd and the strong antioxidative potential of these compounds, as well as their abundance in dietary products, it seems to be of high importance to consider the possibility of using polyphenols as potential preventive and therapeutic agents against Cd hepatotoxicity, determined by its strong pro-oxidative properties. Although most of the data on the effectiveness of polyphenols comes from studies in animals, the fact that some of them are derived from experimental models that reflect human exposure to this metal allows us to assume that some polyphenol-rich food products may be promising protective agents against Cd hepatotoxicity in humans.
最近，科学界越来越关注环境污染物对健康的威胁，包括有毒金属如镉 (Cd)，并需要寻找有效方法来预防和治疗暴露于这些污染物对健康的不利影响。对于 Cd 来说，特别有前途的是利用植物中存在的各种成分，包括主要的多酚化合物。由于肝脏是这种有毒金属的靶器官之一，而该器官的正常功能紊乱对健康有严重后果，因此本次综述的目的是讨论使用富含多酚的食品（如沙棘、黑茶、绿茶、蓝莓、橄榄油、迷迭香和姜）作为防止这种外来物肝毒性和治疗这种重金属诱导的肝损伤的策略的可能性。由于多酚能够结合 Cd 离子，并且这些化合物具有很强的抗氧化潜力，以及它们在膳食产品中的丰富性，因此考虑将多酚作为预防和治疗 Cd 肝毒性的潜在药物具有重要意义，这是由其强烈的促氧化特性决定的。尽管大多数关于多酚有效性的数据来自动物研究，但其中一些来自反映人类接触这种金属的实验模型的事实，使我们可以假设一些富含多酚的食品可能是人类对抗 Cd 肝毒性的有希望的保护剂。
