Department of Ophthalmology, Hanyang University Hospital, Seoul, Korea.
Department of Biomedical Engineering, Hanyang University College of Medicine, Seoul, Korea.
PLoS One. 2018 Sep 18;13(9):e0204069. doi: 10.1371/journal.pone.0204069. eCollection 2018.
To investigate the effect of eye movement on the optic nerve head (ONH) using swept-source optical coherence tomography (SS-OCT), and to measure the degree of ONH changes.
We enrolled 52 healthy subjects, 20 to 40 years of age, and performed a prospective observational study. Both ONH and macula were imaged simultaneously using wide volume scan of the SS-OCT in the primary and different gaze positions. Horizontal eye movements were used to obtain OCT images in abducted and adducted eyeball positions. Multilateral 3-dimensional registration was used to process and analyze the images to measure the degree of ONH changes.
The mean axial length (AXL) was 25.73 ± 1.42mm and the mean spherical equivalents was -4.49 ± 2.94 D (The proportion of high myopia was 39.4%). Significant morphologic changes were observed in the ONH during both abduction and adduction. In abduction, the overall ONH tissues were elevated, and the mean area of elevation was 115,134 ± 9,424 μm2 (p<0.001). In adduction, the mean areas from two perspectives, which were nasal or temporal, and peripapillary tissues or optic nerve cupping were 95,277 ± 73,846 μm2, 34,450 ± 44,948 μm2, -108,652 ± 91,246 μm2, and -30,581 ± 46,249 μm2, respectively. Elevation in abduction (overall, nasal cup segment, and temporal cup segment; R = 0.204, 0.195 and 0.225, p = 0.038, 0.047 and 0.021, respectively) and elevation of nasal peripapillary segments in adduction were positively correlated with AXL (R = 0.346, p<0.001).
We found significant morphologic changes in the ONH in both abduction and adduction and these changes were associated with AXL. Considering these morphologic changes as physical properties, it allows a better understanding of the biomechanical characteristics of the ONH.
使用扫频源光学相干断层扫描（SS-OCT）研究眼球运动对视神经头（ONH）的影响，并测量 ONH 变化的程度。
我们招募了 52 名 20 至 40 岁的健康受试者，进行了一项前瞻性观察研究。使用 SS-OCT 的宽体积扫描同时对 ONH 和黄斑进行成像，并在原发性和不同注视位置下进行。使用水平眼球运动在眼球外展和内收位置获取 OCT 图像。使用多边 3 维配准处理和分析图像，以测量 ONH 变化的程度。
平均眼轴长度（AXL）为 25.73 ± 1.42mm，平均球镜等效值为-4.49 ± 2.94 D（高度近视的比例为 39.4%）。在眼球外展和内收过程中，ONH 都观察到明显的形态变化。在眼球外展时，整个 ONH 组织抬高，平均抬高面积为 115134 ± 9424 μm2（p<0.001）。在眼球内收时，从鼻侧或颞侧以及视盘周围组织或视神经杯两个角度来看，平均面积分别为 95277 ± 73846 μm2、34450 ± 44948 μm2、-108652 ± 91246 μm2 和-30581 ± 46249 μm2。眼球外展时的抬高（整体、鼻侧杯段和颞侧杯段；R = 0.204、0.195 和 0.225，p = 0.038、0.047 和 0.021，分别）和眼球内收时鼻侧视盘周围节段的抬高与 AXL 呈正相关（R = 0.346，p<0.001）。
我们发现眼球外展和内收时 ONH 存在明显的形态变化，这些变化与 AXL 有关。将这些形态变化视为物理特性，可以更好地了解 ONH 的生物力学特性。
