Yang Seong Baek, Kim Eun Hee, Kim Seung Hee, Kim Young Hun, Oh Weontae, Lee Jin-Tae, Jang Young-Ah, Sabina Yeasmin, Ji Byung Chul, Yeum Jeong Hyun
Department of Advanced Organic Materials Science and Engineering, Kyungpook National University, Daegu 41566, Korea.
Gooworl Co., Ltd., Daegu 41422, Korea.
Nanomaterials (Basel). 2018 Sep 17;8(9):734. doi: 10.3390/nano8090734.
(CC) is used in conventional Chinese medicine. The main active components of CC are isoquinoline alkaloids, including berberine, coptisine, palmatine, and magnoflorine; all these are known to have several pharmacological properties. Poly(vinyl alcohol) (PVA) is a well-known synthetic biocompatible polymer suitable for a range of pharmaceutical uses; it can be used as a matrix for the incorporation of functional materials and has a wide range of applications in the cosmetics, food, pharmaceutical, and packaging industries. In this study, PVA-based electrospun nanofibers containing CC extract were successfully fabricated. Furthermore, the effects of different CC extract contents on the morphologies, and antimicrobial and antifungal properties of PVA/CC extract nanofibers were investigated. Morphological changes were observed using different molecular weights of PVA. For characterization, field-emission scanning electron microscopy, thermogravimetric analysis, and Fourier transform infrared analysis were performed. The effectiveness of these nanofibers has been demonstrated by evaluating the thermal stability against , antimicrobial activity against and , and the antifungal activity against the fungi and . The PVA/CC extract nanofibers were found to have excellent antibacterial and antifungal activity and thermal stability; hence, their use in medicinal sectors is highly recommended.
黄连在传统中药中被使用。黄连的主要活性成分是异喹啉生物碱，包括小檗碱、黄连碱、巴马汀和木兰碱；所有这些成分都具有多种药理特性。聚乙烯醇（PVA）是一种众所周知的合成生物相容性聚合物，适用于一系列药物用途；它可以用作掺入功能材料的基质，并且在化妆品、食品、制药和包装行业有广泛应用。在本研究中，成功制备了含有黄连提取物的基于聚乙烯醇的电纺纳米纤维。此外，研究了不同黄连提取物含量对聚乙烯醇/黄连提取物纳米纤维的形态、抗菌和抗真菌性能的影响。使用不同分子量的聚乙烯醇观察形态变化。为了进行表征，进行了场发射扫描电子显微镜、热重分析和傅里叶变换红外分析。通过评估对……的热稳定性、对……和……的抗菌活性以及对真菌……和……的抗真菌活性，证明了这些纳米纤维的有效性。发现聚乙烯醇/黄连提取物纳米纤维具有优异的抗菌和抗真菌活性以及热稳定性；因此，强烈推荐它们在医药领域的应用。
