细胞介导免疫的个体发生。I. 新生小鼠中同种异体抗原特异性细胞毒性T细胞前体的早期发育。
Ontogeny of cell-mediated immunity. I. Early development of alloantigen-specific cytotoxic T-cell precursors in postnatal mice.
作者信息
Pilarski L M
出版信息
J Exp Med. 1977 Sep 1;146(3):887-92. doi: 10.1084/jem.146.3.887.
Abstract
Cytotoxic T-cell precursors have been shown to occur in spleens of 2-3-day-old mice. By 12 days after birth, the cytotoxic T-cell response of spleen cells to alloantigens has reached 23-32% of adult levels. Addition of extra T-helper cells did not permit cytotoxic T-cell development in spleen cells from newborn to 2-day-old mice suggesting either a lack of precursors or suppression of precursors. The ontogeny of cell-mediated immune functions has thus been shown to correlate well with other work on the development of humoral immunity, accessory cells, and graft versus host reactivity.
摘要
细胞毒性T细胞前体已被证明存在于2 - 3日龄小鼠的脾脏中。出生后12天，脾细胞对同种异体抗原的细胞毒性T细胞反应已达到成年水平的23 - 32%。添加额外的辅助性T细胞并不能使新生至2日龄小鼠的脾细胞发生细胞毒性T细胞发育，这表明要么缺乏前体，要么前体受到抑制。因此，细胞介导的免疫功能的个体发生已被证明与体液免疫、辅助细胞和移植物抗宿主反应发育的其他研究结果密切相关。
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本文引用的文献
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