电子束灭菌对用于骨组织工程的 3D 打印聚己内酯/β-磷酸三钙支架的影响。
Effect of Electron Beam Sterilization on Three-Dimensional-Printed Polycaprolactone/Beta-Tricalcium Phosphate Scaffolds for Bone Tissue Engineering.
机构信息
1 Department of Orthopaedic Surgery and of Bioengineering and of Material Science and Engineering, Stanford University, Stanford, California.
2 Department of Orthopaedic Surgery, of Bioengineering and of Material Science and Engineering, Stanford University, Stanford, California.
出版信息
Tissue Eng Part A. 2019 Feb;25(3-4):248-256. doi: 10.1089/ten.TEA.2018.0130. Epub 2018 Oct 27.
Abstract
Providing customized geometries and improved control in physical and biological properties, 3D-printed polycaprolactone/beta-tricalcium phosphate (PCL/β-TCP) composite constructs are of high interest for bone tissue engineering applications. A critical step toward the translation and clinical applications of these types of scaffolds is terminal sterilization, and E-beam irradiation might be the most relevant method because of PCL properties. Through in vitro experimental testing of both physical and biological properties, it is proven in this article that E-beam irradiation is relevant for sterilization of 3D-printed PCL/β-TCP scaffolds for bone tissue engineering applications.
摘要
3D 打印聚己内酯/β-磷酸三钙（PCL/β-TCP）复合材料构建体在物理和生物学性能方面提供了定制化的几何形状和更好的控制，因此非常适用于骨组织工程应用。这些支架类型转化和临床应用的关键步骤是终端灭菌，而电子束辐照可能是由于 PCL 性能而最相关的方法。通过对物理和生物学性能的体外实验测试，本文证明电子束辐照适用于骨组织工程应用的 3D 打印 PCL/β-TCP 支架的灭菌。
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