School of Life Science and Biotechnology, Dalian University of Technology, No. 2 Linggong Road, Dalian 116024, China.
College of Pharmacy, Dalian Medical University, No. 9 West Section Lvshun South Road, Dalian 116044, China.
Chem Commun (Camb). 2018 Oct 14;54(80):11304-11307. doi: 10.1039/c8cc07047d. Epub 2018 Sep 20.
A supramolecular catiomer with a metal-organic framework (MOF) motif was developed to manufacture messenger RNA (mRNA) assemblies. In contrast to the linear catiomer, the dendritic MOF catiomer appeared to markedly improve the colloidal stability of the mRNA assemblies, particularly affording substantial protection to the mRNA payloads from enzymatic degradation, eventually conducing to appreciable mRNA transfection activities at the targeted cells.
一种具有金属有机骨架（MOF）结构的超分子阳离子聚合物被开发用于制造信使 RNA（mRNA）组装体。与线性阳离子聚合物相比，树枝状 MOF 阳离子聚合物似乎显著提高了 mRNA 组装体的胶体稳定性，特别是为 mRNA 有效负载提供了大量的酶降解保护，最终在靶向细胞中表现出可观的 mRNA 转染活性。
