超越 2D：用于皮肤再生的 3D 生物打印
Beyond 2D: 3D bioprinting for skin regeneration.
机构信息
Tianjin Medical University, Tianjin, China.
Key Laboratory of Tissue Repair and Regeneration of PLA, and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, First Hospital Affiliated to General Hospital of PLA, Beijing, China.
出版信息
Int Wound J. 2019 Feb;16(1):134-138. doi: 10.1111/iwj.13003. Epub 2018 Sep 21.
Essential cellular functions that are present in tissues are missed by two-dimensional (2D) cell monolayer culture. It certainly limits their potential to predict the cellular responses of real organisms. Engineering approaches offer solutions to overcome current limitations. For example, establishing a three-dimensional (3D)-based matrix is motivated by the need to mimic the functions of living tissues, which will have a strong impact on regenerative medicine. However, as a novel approach, it requires the development of new standard protocols to increase the efficiency of clinical translation. In this review, we summarised the various aspects of requirements related to well-suited 3D bioprinting techniques for skin regeneration and discussed how to overcome current bottlenecks and propel these therapies into the clinic.
二维（2D）细胞单层培养会错过组织中存在的基本细胞功能。这确实限制了它们预测真实生物体细胞反应的潜力。工程方法提供了解决当前限制的方案。例如，建立基于三维（3D）的基质是为了模拟活组织的功能，这将对再生医学产生重大影响。然而，作为一种新方法，它需要开发新的标准协议来提高临床转化的效率。在这篇综述中，我们总结了与皮肤再生相关的合适 3D 生物打印技术的各个方面，并讨论了如何克服当前的瓶颈，推动这些疗法进入临床应用。
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