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鉴定流感特异性人类细胞毒性T淋巴细胞识别的病毒分子。

Identification of viral molecules recognized by influenza-specific human cytotoxic T lymphocytes.

作者信息

Gotch F, McMichael A, Smith G, Moss B

出版信息

J Exp Med. 1987 Feb 1;165(2):408-16. doi: 10.1084/jem.165.2.408.

DOI:10.1084/jem.165.2.408
PMID:3029268
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2188513/
Abstract

Human cytotoxic T cells specific for influenza A virus were tested for recognition of each of the ten influenza A virus proteins expressed in target cells using recombinant vaccinia viruses. They recognized the matrix M1, polymerase PB2, and nucleoproteins of influenza virus in association with MHC class I antigens. These internal viral proteins were seen by CTL in conjunction with one or more of the available dependent HLA gene products. There was no detectable recognition of influenza virus surface glycoproteins in target cells.

摘要

利用重组痘苗病毒，对甲型流感病毒特异性的人细胞毒性T细胞进行检测，以识别在靶细胞中表达的十种甲型流感病毒蛋白中的每一种。它们识别与MHC I类抗原相关的甲型流感病毒的基质M1、聚合酶PB2和核蛋白。这些病毒内部蛋白可被细胞毒性T淋巴细胞与一种或多种可用的相关HLA基因产物共同识别。在靶细胞中未检测到对甲型流感病毒表面糖蛋白的识别。

相似文献

1
Identification of viral molecules recognized by influenza-specific human cytotoxic T lymphocytes.鉴定流感特异性人类细胞毒性T淋巴细胞识别的病毒分子。
J Exp Med. 1987 Feb 1;165(2):408-16. doi: 10.1084/jem.165.2.408.
2
Influenza basic polymerase 2 peptides are recognized by influenza nucleoprotein-specific cytotoxic T lymphocytes.流感病毒基本聚合酶2肽段可被流感病毒核蛋白特异性细胞毒性T淋巴细胞识别。
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3
Influenza A virus nucleoprotein is a major target antigen for cross-reactive anti-influenza A virus cytotoxic T lymphocytes.甲型流感病毒核蛋白是交叉反应性抗甲型流感病毒细胞毒性T淋巴细胞的主要靶抗原。
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本文引用的文献

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Cytotoxic T-cell immunity to influenza.针对流感的细胞毒性T细胞免疫
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Construction and characterization of an infectious vaccinia virus recombinant that expresses the influenza hemagglutinin gene and induces resistance to influenza virus infection in hamsters.表达流感血凝素基因并诱导仓鼠对流感病毒感染产生抗性的传染性痘苗病毒重组体的构建与鉴定。
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The influenza A virus nucleoprotein gene controls the induction of both subtype specific and cross-reactive cytotoxic T cells.甲型流感病毒核蛋白基因控制亚型特异性和交叉反应性细胞毒性T细胞的诱导。
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Inhibition of human T lymphocyte function with monoclonal antibodies.用单克隆抗体抑制人T淋巴细胞功能。
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Cytotoxic T lymphocyte recognition of the influenza hemagglutinin gene product expressed by DNA-mediated gene transfer.细胞毒性T淋巴细胞对通过DNA介导的基因转移所表达的流感血凝素基因产物的识别。
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Cytotoxic T cell recognition of the influenza nucleoprotein and hemagglutinin expressed in transfected mouse L cells.细胞毒性T细胞对转染小鼠L细胞中表达的流感核蛋白和血凝素的识别。
Cell. 1984 Nov;39(1):13-25. doi: 10.1016/0092-8674(84)90187-9.
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Influenza A virus nucleoprotein is a major target antigen for cross-reactive anti-influenza A virus cytotoxic T lymphocytes.甲型流感病毒核蛋白是交叉反应性抗甲型流感病毒细胞毒性T淋巴细胞的主要靶抗原。
Proc Natl Acad Sci U S A. 1985 Mar;82(6):1785-9. doi: 10.1073/pnas.82.6.1785.
10
Recognition of influenza A virus nucleoprotein by human cytotoxic T lymphocytes.人细胞毒性T淋巴细胞对甲型流感病毒核蛋白的识别。
J Gen Virol. 1986 Apr;67 ( Pt 4):719-26. doi: 10.1099/0022-1317-67-4-719.