Vandenplas Yvan, Analitis Antonis, Tziouvara Chara, Kountzoglou Athina, Drakou Anastasia, Tsouvalas Manos, Mavroudi Antigoni, Xinias Ioannis
Department of Pediatrics, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
Department of Hygiene, Epidemiology and Medical Statistics, Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Pediatr Gastroenterol Hepatol Nutr. 2017 Sep;20(3):167-177. doi: 10.5223/pghn.2017.20.3.167. Epub 2017 Sep 26.
Breastfeeding is the best way to feed all infants, but not all infants can be (exclusively) breastfed. Cow's milk based infant formula is the second choice infant feeding.
The safety of a new synbiotic infant formula, supplemented with and fructo-oligosaccharides, with lactose and a whey/casein 60/40 protein ratio was tested in 280 infants during 3 months.
The median age of the infants at inclusion was 0.89 months. Weight evolution was in accordance with the World Health Organization growth charts for exclusive breastfed infants. The evolution of all anthropometric parameters (weight-for-length z score and body mass index-for-age z score) was within the normal range. The incidence of functional constipation (3.2%), daily regurgitation (10.9%), infantile crying and colic (10.5%) were all significantly lower than the reported median prevalence for a similar age according to literature (median value of 7.8% for functional constipation, 26.7% for regurgitation, 17.7% for infantile colic).
The new synbiotic infant starter formula was safe, resulted in normal growth and was well tolerated. Functional gastro-intestinal manifestations (functional constipation, regurgitation and colic) were significantly lower than reported in literature. Synbiotics ( and fructo-oligosaccharides) in cow's milk based infant formula bring the second choice infant feeding, formula, closer to the golden standard, exclusive breastfeeding.
母乳喂养是喂养所有婴儿的最佳方式，但并非所有婴儿都能（完全）进行母乳喂养。以牛乳为基础的婴儿配方奶粉是婴儿喂养的第二选择。
一种添加了[具体成分未给出]和低聚果糖、含有乳糖且乳清蛋白/酪蛋白比例为60/40的新型合生元婴儿配方奶粉，在280名婴儿中进行了为期3个月的安全性测试。
纳入研究的婴儿中位年龄为0.89个月。体重增长符合世界卫生组织纯母乳喂养婴儿的生长曲线。所有人体测量参数（身长体重Z评分和年龄别体质指数Z评分）的变化均在正常范围内。功能性便秘的发生率（3.2%）、每日反流的发生率（10.9%）、婴儿哭闹和肠绞痛的发生率（10.5%）均显著低于文献报道的同年龄组中位患病率（功能性便秘中位值为7.8%，反流为26.7%，婴儿肠绞痛为17.7%）。
新型合生元婴儿起始配方奶粉安全，能使婴儿正常生长且耐受性良好。功能性胃肠道表现（功能性便秘、反流和肠绞痛）显著低于文献报道。基于牛乳的婴儿配方奶粉中的合生元（[具体成分未给出]和低聚果糖）使第二选择的婴儿喂养配方奶粉更接近黄金标准——纯母乳喂养。
