Feng Lanyun, Qi Qi, Wang Peng, Chen Hao, Chen Zhen, Meng Zhiqiang, Liu Luming
1 Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
2 Department of Oncology, Shanghai Medical College, Shanghai, China.
J Int Med Res. 2018 Dec;46(12):5228-5236. doi: 10.1177/0300060518800588. Epub 2018 Oct 10.
Early detection and prognosis prediction are critical to improve patient survival in pancreatic cancer. This study aimed to investigate whether interleukins could serve as indicators of prognosis in pancreatic cancer.
Sixty-eight patients with pancreatic cancer were enrolled in the study during the period between 2012 and 2014. The serum levels of a broad spectrum of interleukins in these patients were determined, including IL-1β, IL-2, IL-6, IL-8, IL-10, IL-13, IL-15, and IL-23.
IL-6, IL-8, and IL-10 showed significant positive correlations with each other. Moreover, high levels of serum IL-6, IL-8, and IL-10 were independently strongly associated with poor survival of patients with pancreatic cancer.
Our results suggest that serum levels of IL-6, IL-8, and IL-10 could be useful markers for prediction of prognosis in patients with pancreatic cancer.
早期检测和预后预测对于提高胰腺癌患者的生存率至关重要。本研究旨在探讨白细胞介素是否可作为胰腺癌预后的指标。
2012年至2014年期间，68例胰腺癌患者纳入本研究。测定这些患者血清中多种白细胞介素的水平，包括IL-1β、IL-2、IL-6、IL-8、IL-10、IL-13、IL-15和IL-23。
IL-6、IL-8和IL-10之间呈显著正相关。此外，血清IL-6、IL-8和IL-10水平高与胰腺癌患者的不良生存独立且密切相关。
我们的结果表明，血清IL-6、IL-8和IL-10水平可能是预测胰腺癌患者预后的有用标志物。
