具有染料吸附和药物包封特性的热开关型新型离子液体基凝胶剂。
Thermo-Switchable de Novo Ionic Liquid-Based Gelators with Dye-Absorbing and Drug-Encapsulating Characteristics.
作者信息
Kuddushi Muzammil, Patel Nehal K, Rajput Sargam, Shah Ankit, El Seoud Omar A, Malek Naved I
机构信息
Applied Chemistry Department, S. V. National Institute of Technology, Surat 395007 Gujarat, India.
Institute of Chemistry, The University of Sao Paulo, 748 Prof. Lineu Prestes Av., São Paulo, São Paulo 05508-000, Brazil.
出版信息
ACS Omega. 2018 Sep 30;3(9):12068-12078. doi: 10.1021/acsomega.8b01984. Epub 2018 Sep 27.
An ionic liquid-based surfactant with ester functionality self-aggregates in an aqueous medium and forms ionogels at 8.80% (w/v) concentration at physiological pH. The ionogel exhibited a remarkable change in its appearance with temperature from fibrillar opaque to transparent because of the dynamic changes within its supramolecular structure. This gel-to-gel phase transition occurs below the melting point of the solid ionic liquid. The ionogels were investigated using turbidity, differential scanning calorimetry, scanning electron microscopy (SEM), field emission SEM (FE-SEM), inverted microscopy, transmission electron microscopy imaging, Fourier transform infrared spectroscopy, and rheological measurements. The fibrillar opaque ionogel and transparent ionogel were studied for their ability to absorb dyes (methyl orange and crystal violet) and to encapsulate drugs (diclofenac sodium and imatinib mesylate).
一种具有酯功能的离子液体基表面活性剂在水介质中自聚集，并在生理pH值下浓度为8.80%（w/v）时形成离子凝胶。由于其超分子结构内的动态变化，离子凝胶的外观随温度发生了显著变化，从纤维状不透明变为透明。这种凝胶到凝胶的相变发生在固体离子液体的熔点以下。使用浊度、差示扫描量热法、扫描电子显微镜（SEM）、场发射扫描电子显微镜（FE-SEM）、倒置显微镜、透射电子显微镜成像、傅里叶变换红外光谱和流变学测量对离子凝胶进行了研究。研究了纤维状不透明离子凝胶和透明离子凝胶吸收染料（甲基橙和结晶紫）和包封药物（双氯芬酸钠和甲磺酸伊马替尼）的能力。
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