Opt Lett. 2018 Oct 15;43(20):5162-5165. doi: 10.1364/OL.43.005162.
Optical coherence tomography (OCT) has emerged as a powerful imaging instrument and technology in biomedicine. OCT imaging is predominantly performed using wavelengths in the near infrared; however, visible light (VIS) has been recently employed in OCT systems with encouraging results for high-resolution retinal imaging. Using a broadband supercontinuum VIS source, we present a sensorless adaptive optics (SAO) multimodal imaging system driven by VIS-OCT for volumetric retinal structural imaging, followed by the acquisition of fluorescence emission. The coherence-gated, depth-resolved VIS-OCT images used for image-guided SAO aberration correction enable high-resolution structural and fluorescence imaging.
光学相干断层扫描（OCT）已成为生物医学领域中一种强大的成像工具和技术。OCT 成像主要使用近红外波长进行；然而，可见光（VIS）最近已被用于 OCT 系统中，为高分辨率视网膜成像带来了令人鼓舞的结果。我们使用宽带超连续 VIS 源，提出了一种基于 VIS-OCT 的无传感器自适应光学（SAO）多模态成像系统，用于进行体积视网膜结构成像，随后获取荧光发射。用于图像引导 SAO 像差校正的相干门控、深度分辨 VIS-OCT 图像可实现高分辨率的结构和荧光成像。
