禽肉瘤病毒17携带原癌基因jun。
Avian sarcoma virus 17 carries the jun oncogene.
作者信息
Maki Y, Bos T J, Davis C, Starbuck M, Vogt P K
出版信息
Proc Natl Acad Sci U S A. 1987 May;84(9):2848-52. doi: 10.1073/pnas.84.9.2848.
Biologically active molecular clones of avian sarcoma virus 17 (ASV 17) contain a replication-defective proviral genome of 3.5 kilobases (kb). The genome retains partial gag and env sequences, which flank a cell-derived putative oncogene of 0.93 kb, termed jun. The jun gene lacks preserved coding domains of tyrosine-specific protein kinases. It also shows no significant nucleic acid homology with other known oncogenes. The probable transformation-specific protein in ASV 17-transformed cells is a 55-kDa gag-jun fusion product.
禽肉瘤病毒17（ASV 17）的生物活性分子克隆包含一个3.5千碱基（kb）的复制缺陷型前病毒基因组。该基因组保留了部分gag和env序列，其两侧是一个0.93 kb的细胞衍生推定癌基因，称为jun。jun基因缺乏酪氨酸特异性蛋白激酶的保守编码结构域。它与其他已知癌基因也没有明显的核酸同源性。ASV 17转化细胞中可能的转化特异性蛋白是一种55 kDa的gag-jun融合产物。
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