Department of Radiology and Advanced Imaging Research Center, 5323 Harry Hines Blvd, UT Southwestern Medical Center, Dallas, TX 75390-8514, USA; Current affiliation: Molecular Imaging Program at Stanford (MIPS) and the Canary Center at Stanford for Cancer Early Detection, Department of Radiology, School of Medicine, Stanford University, Stanford, CA 94305-5427, USA.
Department of Radiology and Advanced Imaging Research Center, 5323 Harry Hines Blvd, UT Southwestern Medical Center, Dallas, TX 75390-8514, USA.
Drug Discov Today. 2019 Feb;24(2):492-504. doi: 10.1016/j.drudis.2018.10.007. Epub 2018 Oct 17.
Stem cell therapies have demonstrated promising preclinical results, but very few applications have reached the clinic owing to safety and efficacy concerns. Translation would benefit greatly if stem cell survival, distribution and function could be assessed in vivo post-transplantation, particularly in patients. Advances in molecular imaging have led to extraordinary progress, with several strategies being deployed to understand the fate of stem cells in vivo using magnetic resonance, scintigraphy, PET, ultrasound and optical imaging. Here, we review the recent advances, challenges and future perspectives and opportunities in stem cell tracking and functional assessment, as well as the advantages and challenges of each imaging approach.
干细胞疗法已经在临床前研究中显示出了有希望的结果，但由于安全性和疗效方面的担忧，很少有应用能够进入临床阶段。如果能够在移植后对干细胞的存活、分布和功能进行体内评估，特别是在患者中进行评估，那么翻译将会有很大的帮助。分子成像技术的进步带来了非凡的进展，已经采用了几种策略来使用磁共振、闪烁成像、正电子发射断层扫描、超声和光学成像来了解体内干细胞的命运。在这里，我们回顾了干细胞示踪和功能评估方面的最新进展、挑战以及未来的前景和机遇，以及每种成像方法的优势和挑战。
