Papazisis Georgios, Siafis Spyridon, Tsakiridis Ioannis, Koulas Ioannis, Dagklis Themistoklis, Kouvelas Dimitrios
Department of Clinical Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Subst Abuse. 2018 Oct 14;12:1178221818805977. doi: 10.1177/1178221818805977. eCollection 2018.
Cannabis is reported to be the most common illicit substance used among medical students; however, the number of related studies is limited and their results are not systematically reviewed. The aim of our study was to analyze the prevalence of lifetime and current use of cannabis among medical students worldwide.
A systematic review and meta-analysis was performed with adherence to the PRISMA guidelines. The electronic databases PubMed, Scopus, and Cochrane library were searched for studies on the prevalence of cannabis use among medical students. Prevalence of lifetime, past-year, and past-month cannabis use was extracted. Pooled prevalence and relative risk for sex were calculated using the random effects model and subgroup analyses were conducted.
A total of 38 observational (cross-sectional and cohort) studies were included (total number of participants 19 932), and most of them were conducted in Europe, Central and Southern America, and the United States. Overall pooled prevalence of lifetime cannabis use was 31.4% (95% confidence interval [CI]: 23.7%-39.6%), past-year use was 17.2% (95% CI: 10.8%-24.6%), and past-month use was 8.8% (95% CI: 5.6%-12.5%). Men displayed higher rates of cannabis use with a pooled relative risk of 1.55 (95% CI: 1.32-1.81). Heterogeneity was high ( > 75%) and there were differences among continents in all outcomes ( < .001).
In conclusion, 1 in 3 medical students has used cannabis, whereas 8.8% were current users. Significant differences among continents were observed, but common finding was that male students tend to consume cannabis more often than female students.
据报道,大麻是医学生中使用最普遍的非法物质;然而,相关研究数量有限,且其结果未得到系统综述。我们研究的目的是分析全球医学生中大麻终生使用和当前使用的流行情况。
按照PRISMA指南进行系统综述和荟萃分析。在电子数据库PubMed、Scopus和Cochrane图书馆中检索关于医学生中大麻使用流行情况的研究。提取大麻终生使用、过去一年使用和过去一个月使用的流行率。使用随机效应模型计算合并流行率和性别相对风险,并进行亚组分析。
共纳入38项观察性(横断面和队列)研究(参与者总数19932人),其中大多数研究在欧洲、中南美洲和美国进行。大麻终生使用的总体合并流行率为31.4%(95%置信区间[CI]:23.7%-39.6%),过去一年使用为17.2%(95%CI:10.8%-24.6%),过去一个月使用为8.8%(95%CI:5.6%-12.5%)。男性的大麻使用率较高,合并相对风险为1.55(95%CI:1.32-1.81)。异质性较高(I²>75%),所有结局在各大洲之间均存在差异(P<0.001)。
总之,三分之一的医学生使用过大麻,而8.8%为当前使用者。观察到各大洲之间存在显著差异,但共同的发现是男学生比女学生更倾向于更频繁地使用大麻。