Unit for Nutrition Research, Faculty of Food Science and Nutrition, Landspitali University Hospital, University of Iceland, Eiriksgata 29, 101, Reykjavik, Iceland.
Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, DK-2300, Copenhagen, Denmark.
Curr Obes Rep. 2018 Dec;7(4):289-293. doi: 10.1007/s13679-018-0321-z.
Dietary treatments for obesity have relatively low long-term success. Recent studies have identified the gastrointestinal microbiome as a factor of high relevance. The current knowledge on the interplay between diet, obesity, and the gastrointestinal microbiome and the potential for individualized dietary treatment will be discussed.
Studies indicate that each individual digests and metabolizes identical food substances differently depending on their gastrointestinal microbiome composition. Factors related to this crosstalk may improve our understanding of weight homeostasis and treatment of obesity. Long-time dietary intake is the key in the composition of the gastrointestinal microbiome which seems to be an important factor for energy balance, resulting in emerging opportunities for increasingly varied obesity treatment. Compliance to dietary treatment is critical for long-term success as enduring changes in gastrointestinal microbiome seem to slow over time. More research is urgently needed to investigate this missing link in our understanding of obesity.
饮食疗法治疗肥胖症的长期成功率相对较低。最近的研究表明，胃肠道微生物组是一个高度相关的因素。本文将讨论饮食、肥胖症和胃肠道微生物组之间的相互作用以及个性化饮食治疗的可能性。
研究表明，每个人根据其胃肠道微生物组组成，对相同的食物物质的消化和代谢方式不同。与这种串扰相关的因素可能会增进我们对体重平衡和肥胖症治疗的理解。长时间的饮食摄入是胃肠道微生物组组成的关键，这似乎是能量平衡的一个重要因素，为肥胖症的治疗提供了更多的机会。饮食治疗的依从性对于长期成功至关重要，因为胃肠道微生物组的持久变化似乎随着时间的推移而减缓。迫切需要更多的研究来探索我们对肥胖症理解中的这一缺失环节。
