成人睡眠剥夺与肥胖：简要叙述性综述
Sleep deprivation and obesity in adults: a brief narrative review.
作者信息
Cooper Christopher B, Neufeld Eric V, Dolezal Brett A, Martin Jennifer L
机构信息
Exercise Physiology Research Laboratory, Departments of Medicine and Physiology, David Geffen School of Medicine at University of California, Los Angeles, California, USA.
Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, California, USA.
出版信息
BMJ Open Sport Exerc Med. 2018 Oct 4;4(1):e000392. doi: 10.1136/bmjsem-2018-000392. eCollection 2018.
BACKGROUND/AIMS: Obesity and sleep deprivation are two epidemics that pervade developed nations. Their rates have been steadily rising worldwide, especially in the USA. This short communication will explore the link between the two conditions and outline the proposed mechanisms behind their relationship.
METHODS
Studies on the topic of sleep and obesity were reviewed, and findings were used to develop a theoretical model for the biological link between short sleep duration and obesity.
RESULTS
Individuals who regularly slept less than 7 hours per night were more likely to have higher average body mass indexes and develop obesity than those who slept more. Studies showed that experimental sleep restriction was associated with increased levels of ghrelin, salt retention and inflammatory markers as well as decreased levels of leptin and insulin sensitivity.
CONCLUSIONS
There may be a link between obesity and sleep deprivation. We recommend further investigations are to elucidate the potential mechanisms.
背景/目的：肥胖和睡眠不足是在发达国家普遍存在的两大流行病。在全球范围内，它们的发病率一直在稳步上升，尤其是在美国。本短文将探讨这两种情况之间的联系，并概述它们之间关系背后的潜在机制。
方法
对睡眠与肥胖主题的研究进行了综述，并利用研究结果建立了一个关于短睡眠时间与肥胖之间生物学联系的理论模型。
结果
每晚经常睡眠少于7小时的个体比睡眠较多的个体更有可能具有更高的平均体重指数并患上肥胖症。研究表明，实验性睡眠限制与胃饥饿素水平升高、盐分潴留和炎症标志物增加以及瘦素水平和胰岛素敏感性降低有关。
结论
肥胖与睡眠不足之间可能存在联系。我们建议进一步开展调查以阐明潜在机制。
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