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巴西东北部乳腺癌与人乳头瘤病毒（HPV）感染的关联：分子证据

Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence.

作者信息

Cavalcante José Roosevelt, Pinheiro Luiz Gonzaga Porto, Almeida Paulo Roberto Carvalho de, Ferreira Márcia Valéria Pitombeira, Cruz Gizele Almada, Campelo Thales Alves, Silva Caroliny Soares, Lima Luana Nepomuceno Gondim Costa, Oliveira Bruno Masato Kitagawa de, Lima Lara Mulato, Feitosa Laura Magda Costa, Pinheiro Agostinho Câmara, Frota Cristiane Cunha

机构信息

Departamento de Cirurgia e Maternidade Escola Assis Chateaubriand, Faculdade de Medicina, Universidade Federal Ceara (UFC), Fortaleza, CE, BR.

Departamento de Patologia e Medicina Legal, Faculdade de Medicina, Universidade Federal Ceara (UFC), Fortaleza, CE, BR.

出版信息

Clinics (Sao Paulo). 2018 Oct 18;73:e465. doi: 10.6061/clinics/2018/e465.

DOI:10.6061/clinics/2018/e465
PMID:30365827
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6172977/
Abstract

OBJECTIVE

The aim of this study is to investigate the presence of human papillomavirus DNA and genotypes in breast cancer and normal breast tissue samples obtained from women from the northeast region of Brazil.

METHOD

One hundred three breast cancer samples and 95 normal breast samples, as the non-malignant controls, were studied. DNA extraction was verified by human beta-globin gene amplification, and polymerase chain reaction was conducted based on HPV L1-specific consensus primers MY09/MY11 and GP5+/GP6+, followed by nested multiplex polymerase chain reaction with type-specific primers for the E6/E7 consensus region.

RESULTS

Human papillomavirus DNA was detected in 51 (49.5%) breast carcinoma samples and 15 (15.8%) normal breast samples (p<0.0001). Human papillomavirus genotypes 6 and 11 were identified in 15.2% of all samples.

CONCLUSIONS

The high frequency of human papillomavirus infection in breast cancer samples indicates a potential role of this virus in breast carcinogenesis in the studied participants.

摘要

目的

本研究旨在调查从巴西东北地区女性获取的乳腺癌组织样本和正常乳腺组织样本中人类乳头瘤病毒DNA及基因型的存在情况。

方法

研究了103例乳腺癌样本和95例正常乳腺样本（作为非恶性对照）。通过人β-珠蛋白基因扩增验证DNA提取情况，并基于HPV L1特异性共有引物MY09/MY11和GP5+/GP6+进行聚合酶链反应，随后使用针对E6/E7共有区域的型特异性引物进行巢式多重聚合酶链反应。

结果

在51例（49.5%）乳腺癌样本和15例（15.8%）正常乳腺样本中检测到人类乳头瘤病毒DNA（p<0.0001）。在所有样本的15.2%中鉴定出人类乳头瘤病毒基因型6和11。

结论

乳腺癌样本中人类乳头瘤病毒感染的高频率表明该病毒在本研究参与者的乳腺癌发生中可能发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1371/6172977/d823be9d1c4c/cln-73-e465-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1371/6172977/d823be9d1c4c/cln-73-e465-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1371/6172977/d823be9d1c4c/cln-73-e465-g001.jpg

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