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硅水凝胶隐形眼镜过夜佩戴后角膜上皮和Bowman层的厚度变化。

Thickness changes in the corneal epithelium and Bowman's layer after overnight wear of silicone hydrogel contact lenses.

作者信息

Lu Fan, Tao Aizhu, Tao Weiwei, Zhuang Xiran, Shen Meixiao

机构信息

School of Ophthalmology and Optometry, Wenzhou Medical University, 270 Xueyuan Road, Wenzhou, Zhejiang, 325027, China.

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

出版信息

BMC Ophthalmol. 2018 Nov 3;18(1):286. doi: 10.1186/s12886-018-0956-2.

DOI:10.1186/s12886-018-0956-2
PMID:30390645
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6215685/
Abstract

BACKGROUND

To investigate thickness changes in the corneal epithelium and Bowman's layer after overnight silicone hydrogel contact lens (CL) wear by using ultra-high resolution optical coherence tomography (UHROCT).

METHODS

Eleven subjects without CL wearing history were recruited for this study. An UHROCT was used to measure the thickness of the epithelium (ET), Bowman's layer (BT), stroma (ST), and total cornea (CCT) at the center of both eyes. A silicone hydrogel CL was inserted in the right eye of each subject, and the fellow non-CL wearing left eye served as the control. The lens was inserted at 9:30 pm and removed at 8:00 am the next morning. The subjects were evaluated at 9:00 pm (baseline), 9:30 pm (lens insertion), 10:00 pm (before sleep), 7:00 am (waking), 7:30 am, and 8:00 am (lens removal).

RESULTS

Compared to the lens insertion level, the ET of the lens-wearing eye increased by 5.73% at eye opening (P = 0.001). The ET of the non-CL wearing eye and the BT in both eyes did not change after overnight CL wear. Compared to baseline, the CCT of the lens-wearing eye increased by 2.87% upon waking (P = 0.003) and recovered 30 min later (P = 0.555). In contrast, compared to baseline, the CCT of the non-CL wearing eye did not increase upon waking (P = 0.105).

CONCLUSIONS

By using UHROCT, we found that overnight CL wear induced different swelling responses in the various sublayers of the cornea.

TRIAL REGISTRATION

Retrospectively registered. Registration number: ChiCTR1800015115 . Registered 07 March 2018.

摘要

背景

采用超高分辨率光学相干断层扫描（UHROCT）研究过夜佩戴硅水凝胶隐形眼镜（CL）后角膜上皮和Bowman层的厚度变化。

方法

招募11名无CL佩戴史的受试者进行本研究。使用UHROCT测量双眼中心的上皮厚度（ET）、Bowman层厚度（BT）、基质厚度（ST）和角膜总厚度（CCT）。在每位受试者的右眼插入硅水凝胶CL，未佩戴CL的左眼作为对照。镜片于晚上9:30插入，第二天早上8:00取出。在晚上9:00（基线）、晚上9:30（镜片插入）、晚上10:00（睡前）、早上7:00（醒来）、早上7:30和早上8:00（镜片取出）对受试者进行评估。

结果

与镜片插入时相比，佩戴镜片眼的ET在睁眼时增加了5.73%（P = 0.001）。过夜佩戴CL后，未佩戴CL眼的ET和双眼的BT均未改变。与基线相比，佩戴镜片眼的CCT在醒来时增加了2.87%（P = 0.003），30分钟后恢复（P = 0.555）。相比之下，与基线相比，未佩戴CL眼的CCT在醒来时没有增加（P = 0.105）。

结论

通过使用UHROCT，我们发现过夜佩戴CL会引起角膜各亚层不同的肿胀反应。

试验注册

回顾性注册。注册号：ChiCTR1800015115。2018年3月7日注册。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24dc/6215685/fb5e32580a98/12886_2018_956_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24dc/6215685/e79b2ee77543/12886_2018_956_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24dc/6215685/ede13bf0c31c/12886_2018_956_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24dc/6215685/b6e267cc2e3a/12886_2018_956_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24dc/6215685/877d97b2f4f4/12886_2018_956_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24dc/6215685/cdcde896c2ac/12886_2018_956_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24dc/6215685/27d9cbf9dd4b/12886_2018_956_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24dc/6215685/fb5e32580a98/12886_2018_956_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24dc/6215685/e79b2ee77543/12886_2018_956_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24dc/6215685/ede13bf0c31c/12886_2018_956_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24dc/6215685/b6e267cc2e3a/12886_2018_956_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24dc/6215685/877d97b2f4f4/12886_2018_956_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24dc/6215685/cdcde896c2ac/12886_2018_956_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24dc/6215685/27d9cbf9dd4b/12886_2018_956_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24dc/6215685/fb5e32580a98/12886_2018_956_Fig7_HTML.jpg

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