Kamal Brishna S, Kamal Fatima, Lantela Daniel E
Whistler Therapeutics, Whistler, BC, Canada.
Whistler Medical Marijuana, Whistler, BC, Canada.
Front Neurosci. 2018 Oct 22;12:730. doi: 10.3389/fnins.2018.00730. eCollection 2018.
is a medicinal herb with a diverse range of chemotypes that can exert both anxiolytic and anxiogenic effects on humans. Medical cannabis patients receiving organically grown cannabis from a single source were surveyed about the effectiveness of cannabis for treating anxiety. Patients rated cannabis as highly effective overall for treating anxiety with an average score of 8.03 on a Likert scale of 0 to 10 (0 = not effective, 10 = extremely effective). Patients also identified which strains they found the most or least effective for relieving their symptoms of anxiety. To find correlations between anxiolytic activity and chemotype, the top four strains voted most and least effective were analyzed by HPLC-MS/MS to quantify cannabinoids and GC-MS to quantify terpenes. Tetrahydrocannabinol (THC) and trans-nerolidol have statistically significant correlations with increased anxiolytic activity. Guiaol, eucalyptol, γ-terpinene, α-phellandrene, 3-carene, and sabinene hydrate all have significant correlations with decreased anxiolytic activity. Further studies are needed to better elucidate the entourage effects that contribute to the anxiolytic properties of cannabis varieties.
是一种具有多种化学类型的药草，对人类既能产生抗焦虑作用，也能产生致焦虑作用。对从单一来源接受有机种植大麻的医用大麻患者进行了关于大麻治疗焦虑有效性的调查。患者对大麻治疗焦虑的总体评价很高，在0至10的李克特量表上平均得分为8.03（0 = 无效，10 = 极其有效）。患者还指出了他们认为对缓解焦虑症状最有效和最无效的菌株。为了找出抗焦虑活性与化学类型之间的相关性，通过HPLC-MS/MS分析了投票选出的最有效和最无效的前四种菌株，以量化大麻素，并通过GC-MS量化萜类化合物。四氢大麻酚（THC）和反式橙花叔醇与抗焦虑活性增加具有统计学上的显著相关性。愈创木酚、桉叶油素、γ-萜品烯、α-水芹烯、3-蒈烯和水合桧烯均与抗焦虑活性降低具有显著相关性。需要进一步研究以更好地阐明促成大麻品种抗焦虑特性的协同效应。
