Paprocki Daniel, Madej Arleta, Koszelewski Dominik, Brodzka Anna, Ostaszewski Ryszard
Institute of Organic Chemistry, Polish Academy of Sciences, Warsaw, Poland.
Front Chem. 2018 Oct 22;6:502. doi: 10.3389/fchem.2018.00502. eCollection 2018.
Multicomponent reactions are powerful synthetic tools for the efficient creation of complex organic molecules in an one-pot one-step fashion. Moreover, the amount of solvents and energy needed for separation and purification of intermediates is significantly reduced what is beneficial from the green chemistry issues point of view. This review highlights the development of multicomponent reactions conducted using aqueous micelles systems during the last two decades.
多组分反应是强大的合成工具,能够以一锅一步法高效构建复杂有机分子。此外,从绿色化学角度来看,中间体分离和纯化所需的溶剂量和能量显著减少,这是有益的。本综述重点介绍了过去二十年中使用水性胶束体系进行的多组分反应的发展情况。