Coleman D V, Gardner S D, Field A M
Br Med J. 1973 Aug 18;3(5876):371-5. doi: 10.1136/bmj.3.5876.371.
Cytological and virological studies on 74 patients with functioning renal allografts were undertaken to detect polyomavirus infection of the renal tract. Ten patients (13.5%) were excreting polyomavirus. Virus particles were seen in the electron microscope in urine samples from eight patients. B.K. polyomavirus was isolated from four patients. Infection with a different polyomavirus was probable in one patient. Virus isolation was most readily achieved when large numbers of intact virus particles were seen in the urine. Patients who were excreting large amounts of polyomavirus shed numerous inclusion-bearing cells which could be detected by cytology. A serological study showed that the prevalence of B.K. antibody was similar to that found in the general population and 38% of this series of transplant patients had evidence of active infection with B.K. virus.
对74例有功能的同种异体肾移植患者进行了细胞学和病毒学研究，以检测肾盂的多瘤病毒感染情况。10例患者（13.5%）排出多瘤病毒。在8例患者的尿液样本中，通过电子显微镜观察到了病毒颗粒。从4例患者中分离出了BK多瘤病毒。1例患者可能感染了另一种多瘤病毒。当在尿液中看到大量完整的病毒颗粒时，最容易实现病毒分离。排出大量多瘤病毒的患者会脱落大量含包涵体的细胞，这些细胞可通过细胞学检测到。血清学研究表明，BK抗体的流行率与普通人群相似，这组移植患者中有38%有BK病毒活跃感染的证据。
