Chiou Brian, Connor James R
Department of Neurosurgery, Penn State College of Medicine, Hershey, PA 17033, USA.
Pharmaceuticals (Basel). 2018 Nov 13;11(4):124. doi: 10.3390/ph11040124.
Ferritin, a ubiquitously expressed protein, has classically been considered the main iron cellular storage molecule in the body. Owing to the ferroxidase activity of the H-subunit and the nucleation ability of the L-subunit, ferritin can store a large amount of iron within its mineral core. However, recent evidence has demonstrated a range of abilities of ferritin that extends well beyond the scope of iron storage. This review aims to discuss novel functions and biomedical uses of ferritin in the processes of iron delivery, delivery of biologics such as chemotherapies and contrast agents, and the utility of ferritin as a biomarker in a number of neurological diseases.
铁蛋白是一种广泛表达的蛋白质，传统上一直被认为是体内主要的细胞内铁储存分子。由于H亚基的铁氧化酶活性和L亚基的成核能力，铁蛋白能够在其矿物核心内储存大量的铁。然而，最近的证据表明，铁蛋白具有一系列的功能，其范围远远超出了铁储存的范畴。本综述旨在探讨铁蛋白在铁传递、化疗和造影剂等生物制剂的传递过程中的新功能和生物医学用途，以及铁蛋白作为多种神经系统疾病生物标志物的效用。
