Chen Ming, Hu Xianglong, Liu Junkai, Li Baixue, Leung Nelson L C, Viglianti Lucia, Cheung Tsz Shing, Sung Herman H Y, Kwok Ryan T K, Williams Ian D, Qin Anjun, Lam Jacky W Y, Tang Ben Zhong
Department of Chemistry , Hong Kong Branch of Chinese National Engineering , Research Center for Tissue Restoration and Reconstruction , Institute of Advanced Study , State Key Laboratory of Molecular Nanoscience , Division of Life Science and Diversion of Biomedical Engineering , The Hong Kong University of Science and Technology , Clear Water Bay, Kowloon , Hong Kong , China . Email:
MOE Key Laboratory of Laser Life Science , Institute of Laser Life Science , College of Biophotonics , South China Normal University , Guangzhou , 510631 , China.
Chem Sci. 2018 Aug 21;9(40):7829-7834. doi: 10.1039/c8sc02810a. eCollection 2018 Oct 28.
The development of new aggregation-induced emission (AIE) systems is a hot research topic, from which functional materials with diversified structures and properties are derived. Here, based on rare, non-emissive and highly electron-withdrawing heteroaromatics of 1,4,5,8-tetraazaanthracene (TAA), experimental and theoretical studies reveal that attaching phenyl rotors to TAA is crucial to creating a new N-type AIE core structure. Furthermore, by covalent attachment of electron-donating aromatic amines to the peripheries of the AIE core, red AIEgens could be obtained readily, which exhibit excellent photostability for long-term lysosome tracking. This work not only provides a new strategy to design heterocycle-containing AIEgens from non-emissive heteroaromatics but also stimulates more their applications as bio-imaging materials.
新型聚集诱导发光（AIE）体系的开发是一个热门研究课题，从中衍生出具有多样结构和性质的功能材料。在此，基于1,4,5,8-四氮杂蒽（TAA）这种稀有、无发射且具有强吸电子性的杂芳烃，实验和理论研究表明，将苯基转子连接到TAA上对于创建一种新的N型AIE核心结构至关重要。此外，通过将给电子芳香胺共价连接到AIE核心的外围，可以很容易地获得红色AIEgens，它们在长期溶酶体追踪中表现出优异的光稳定性。这项工作不仅提供了一种从无发射杂芳烃设计含杂环AIEgens的新策略，还激发了它们作为生物成像材料的更多应用。
