Brasseur P, Kouamouo J, Brandicourt O, Moyou-Somo R, Druilhe P
Laboratoire de Parasitologie, Hotel Dieu, Rouen, France.
Am J Trop Med Hyg. 1988 Aug;39(2):166-72. doi: 10.4269/ajtmh.1988.39.166.
The drug sensitivity of 246 Plasmodium falciparum isolates was studied in vitro in five areas of Cameroon at the end of 1985. Results demonstrate that parasites resistant either to chloroquine, quinine, or mefloquine, or to two of these drugs, were prevalent in four of the areas investigated, but the drug response pattern varies widely from one area to another. The recent explosive emergence of chloroquine resistance in the south of the country, where both prevalences and levels are very high (up to 86%), contrasts with only moderate levels of resistance in the north. This may be related to differences in transmission by mosquitoes between Sahel and forest areas. Quinine resistance was observed in 24% of the isolates studied in vitro and was frequently associated with chloroquine resistance. The presence of isolates responding poorly to mefloquine, observed mainly in northern Cameroon, suggests that resistance may occur in areas where the drug has never been used.
1985年底，在喀麦隆的五个地区对246株恶性疟原虫分离株进行了体外药敏研究。结果表明，对氯喹、奎宁或甲氟喹耐药，或对其中两种药物耐药的寄生虫在四个调查地区普遍存在，但不同地区的药物反应模式差异很大。该国南部氯喹耐药性最近呈爆发式出现，其流行率和耐药水平都非常高（高达86%），而北部的耐药水平仅为中等。这可能与萨赫勒地区和森林地区蚊子传播的差异有关。在体外研究的分离株中，有24%观察到奎宁耐药，且常常与氯喹耐药相关。主要在喀麦隆北部观察到对甲氟喹反应不佳的分离株，这表明在从未使用过该药物的地区可能出现耐药性。
