Knowles G, Davidson W L, Jolley D, Alpers M P
Trans R Soc Trop Med Hyg. 1984;78(2):146-50. doi: 10.1016/0035-9203(84)90260-8.
We have measured the in vitro response of several isolates of Plasmodium falciparum to chloroquine, quinine and mefloquine. We show that parasites which are resistant to chloroquine also have a reduced sensitivity to quinine. However, there appears to be no correlation between chloroquine resistance and reduced sensitivity to mefloquine. We conclude that the emergence and spread of chloroquine resistance could also be establishing a population of parasites with a reduced sensitivity to quinine which may provide the basis for the eventual emergence of quinine resistance.
我们已测定了几种恶性疟原虫分离株对氯喹、奎宁和甲氟喹的体外反应。我们发现，对氯喹耐药的疟原虫对奎宁的敏感性也降低。然而，氯喹耐药性与对甲氟喹敏感性降低之间似乎没有相关性。我们得出结论，氯喹耐药性的出现和传播可能也在产生一群对奎宁敏感性降低的疟原虫，这可能为奎宁耐药性的最终出现奠定基础。
