Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA 23507, USA.
Nutrients. 2018 Nov 14;10(11):1762. doi: 10.3390/nu10111762.
Sepsis is a devastating disease that carries an enormous toll in terms of human suffering and lives lost. Over 100 novel pharmacologic agents that targeted specific molecules or pathways have failed to improve the outcome of sepsis. Preliminary data suggests that the combination of Hydrocortisone, Ascorbic Acid and Thiamine (HAT therapy) may reduce organ failure and mortality in patients with sepsis and septic shock. HAT therapy is based on the concept that a combination of readily available, safe and cheap agents, which target multiple components of the host's response to an infectious agent, will synergistically restore the dysregulated immune response and thereby prevent organ failure and death. This paper reviews the rationale for HAT therapy with a focus on vitamin C.
脓毒症是一种毁灭性的疾病，给人类带来了巨大的痛苦和生命损失。超过 100 种新型的针对特定分子或途径的药物治疗未能改善脓毒症的结局。初步数据表明，氢化可的松、抗坏血酸和硫胺素（HAT 治疗）的联合治疗可能减少脓毒症和感染性休克患者的器官衰竭和死亡率。HAT 治疗的基础是，联合使用现成的、安全且廉价的药物，这些药物针对宿主对感染因子反应的多个组成部分，将协同恢复失调的免疫反应，从而预防器官衰竭和死亡。本文综述了 HAT 治疗的基本原理，重点是维生素 C。
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