Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, PR China.
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, PR China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, PR China.
Phytochemistry. 2019 Feb;158:13-19. doi: 10.1016/j.phytochem.2018.10.035. Epub 2018 Nov 15.
Seven compounds including four undescribed fusaric acid derivatives, namely fusaricates H-K, and two undescribed γ-pyrone derivatives, named fusolanones A-B, as well as a known compound fusaric acid, were isolated from a mangrove endophytic fungus Fusarium solani. Fusaricates H-K represent the first cases of fusaric acid butanediol esters and are diastereoisomers. Their structures including absolute configurations were elucidated based on NMR, MS, chemical synthesis, chiral HPLC analysis and ECD calculations. The antibacterial activity of all undescribed compounds were tested and fusolanone B showed the best activity with MIC value 6.25 μg/mL on Vibrio parahaemolyticus.
从红树林内生真菌尖孢镰刀菌中分离得到 7 种化合物，包括 4 种未描述的 Fusaric acid 衍生物（fusaricates H-K）和 2 种未描述的γ-吡喃酮衍生物（fusolanones A-B），以及一种已知化合物 Fusaric acid。Fusaricates H-K 代表 Fusaric acid 的丁二醇酯的首例，且为非对映异构体。它们的结构包括绝对构型是基于 NMR、MS、化学合成、手性 HPLC 分析和 ECD 计算来阐明的。对所有未描述的化合物进行了抗菌活性测试，fusolanone B 对副溶血弧菌的 MIC 值为 6.25μg/mL，表现出最好的活性。
