芦氟沙星和环丙沙星对感染脆弱拟杆菌小鼠T细胞亚群及肿瘤坏死因子产生的体内效应
In vivo effects of rufloxacin and ciprofloxacin on T-cell subsets and tumor necrosis factor production in mice infected with Bacteroides fragilis.
作者信息
Gollapudi S V, Chuah S K, Harvey T, Thadepalli H D, Thadepalli H
机构信息
Department of Internal Medicine, Charles R. Drew University of Medicine and Science, UCLA School of Medicine 90059.
出版信息
Antimicrob Agents Chemother. 1993 Aug;37(8):1711-2. doi: 10.1128/AAC.37.8.1711.
Abstract
We investigated the in vivo effects of rufloxacin and ciprofloxacin on T-cell subsets and tumor necrosis factor production in mice infected with Bacteroides fragilis. These quinolones did not alter the helper/suppressor ratio but did modulate the kinetics of tumor necrosis factor production in infected animals. This result correlated with the observed therapeutic efficacies of the quinolones.
摘要
我们研究了芦氟沙星和环丙沙星对感染脆弱拟杆菌的小鼠体内T细胞亚群及肿瘤坏死因子产生的影响。这些喹诺酮类药物未改变辅助/抑制细胞比例，但确实调节了感染动物体内肿瘤坏死因子产生的动力学。这一结果与观察到的喹诺酮类药物的治疗效果相关。
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