Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology (DFS), Federal University of Sergipe (UFS), São Cristóvão, SE, Brazil.
Faculty of Science and Technology, University of La Rochelle, La Rochelle, France.
Food Chem Toxicol. 2019 Jan;123:459-469. doi: 10.1016/j.fct.2018.11.030. Epub 2018 Nov 16.
Many diseases, such as inflammatory and central nervous system disorders, currently have a limited number of effective side-effect free treatments. Citronellol (CT) is a monoterpene alcohol present in the essential oil of several plants used in cooking and traditional medicine, such as those of the genus Cymbopogon and Citrus, with pharmacological activities already described in the literature. The aim of this review was to summarize the pharmacological activities already attributed to CT that could be used in treatments for humans. The databases PubMed, MedLine, Scopus, Lilacs and Scielo were searched using the terms "Citronellol" and "Drug effect". 32 articles were identified and used in the study. Twenty-one articles demonstrated CT activities, including antibiotic and antifungal effects in vitro, and 11 properties including analgesic and anticonvulsant effects in vivo, besides presenting low toxicity. In view of the need to discover new drugs and the activities reported for CT, it can be stated that CT is a promising molecule to target in future pharmacological studies.
许多疾病，如炎症和中枢神经系统疾病，目前有效的无副作用的治疗方法有限。香茅醇（CT）是一种单萜醇，存在于几种用于烹饪和传统医学的植物的精油中，如香茅属和柑橘属植物，其药理学活性已在文献中描述。本综述的目的是总结已归因于 CT 的药理学活性，这些活性可用于人类的治疗。使用术语“Citronellol”和“Drug effect”在 PubMed、MedLine、Scopus、Lilacs 和 Scielo 数据库中进行了检索，共确定了 32 篇文章并在研究中使用。21 篇文章证明了 CT 的活性，包括体外的抗生素和抗真菌作用，以及 11 种体内的特性，包括镇痛和抗惊厥作用，此外毒性较低。鉴于需要发现新的药物以及 CT 报道的活性，可以说 CT 是未来药理学研究中有前途的靶向分子。
