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基于石墨烯结构的生物医学应用。

Biomedical Applications of Graphene-Based Structures.

作者信息

Tadyszak Krzysztof, Wychowaniec Jacek K, Litowczenko Jagoda

机构信息

NanoBioMedical Centre, Adam Mickiewicz University, ul. Umultowska 85, PL61614 Poznań, Poland.

School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland.

出版信息

Nanomaterials (Basel). 2018 Nov 16;8(11):944. doi: 10.3390/nano8110944.

Abstract

Graphene and graphene oxide (GO) structures and their reduced forms, e.g., GO paper and partially or fully reduced three-dimensional (3D) aerogels, are at the forefront of materials design for extensive biomedical applications that allow for the proliferation and differentiation/maturation of cells, drug delivery, and anticancer therapies. Various viability tests that have been conducted in vitro on human cells and in vivo on mice reveal very promising results, which make graphene-based materials suitable for real-life applications. In this review, we will give an overview of the latest studies that utilize graphene-based structures and their composites in biological applications and show how the biomimetic behavior of these materials can be a step forward in bridging the gap between nature and synthetically designed graphene-based nanomaterials.

摘要

石墨烯和氧化石墨烯(GO)结构及其还原形式,例如GO纸以及部分或完全还原的三维(3D)气凝胶,处于材料设计的前沿,可用于广泛的生物医学应用,这些应用能够促进细胞增殖和分化/成熟、药物递送以及抗癌治疗。已在体外对人类细胞以及在体内对小鼠进行的各种活力测试显示出非常有前景的结果,这使得基于石墨烯的材料适用于实际应用。在本综述中,我们将概述利用基于石墨烯的结构及其复合材料在生物应用方面的最新研究,并展示这些材料的仿生行为如何能够在弥合天然与合成设计的基于石墨烯的纳米材料之间的差距方面向前迈出一步。

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